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MIDN midnolin [ Homo sapiens (human) ]

Gene ID: 90007, updated on 4-Jan-2025

Summary

Official Symbol
MIDNprovided by HGNC
Official Full Name
midnolinprovided by HGNC
Primary source
HGNC:HGNC:16298
See related
Ensembl:ENSG00000167470 MIM:606700; AllianceGenome:HGNC:16298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Stx
Summary
Enables molecular adaptor activity. Involved in proteasomal ubiquitin-independent protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 27.5), gall bladder (RPKM 18.8) and 25 other tissues See more
Orthologs
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Genomic context

See MIDN in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1248583..1259143)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1217106..1227667)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1248582..1259142)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9673 Neighboring gene ATP synthase F1 subunit delta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1245978-1246723 Neighboring gene uncharacterized LOC102723811 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1248659-1249192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1251037-1251976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13601 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9690 Neighboring gene IQ motif and SEC7 domain-containing protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13604 Neighboring gene uncharacterized LOC105372236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9692 Neighboring gene CIRBP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9695 Neighboring gene cold inducible RNA binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • DKFZp547M072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding PubMed 
enables molecular adaptor activity PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytosol  
located_in nucleolus  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
midnolin
Names
midbrain nucleolar protein
stuxnet homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388306.1NP_001375235.1  midnolin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Consensus CDS
    CCDS92478.1
    UniProtKB/TrEMBL
    A0A804HKJ8
    Related
    ENSP00000507955.1, ENST00000682408.1
    Conserved Domains (1) summary
    cd01804
    Location:31100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins
  2. NM_001388307.1NP_001375236.1  midnolin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Conserved Domains (1) summary
    cd01804
    Location:31100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins
  3. NM_001388474.1NP_001375403.1  midnolin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Consensus CDS
    CCDS32864.1
    UniProtKB/Swiss-Prot
    Q504T8, Q96BW8
    Related
    ENSP00000467679.1, ENST00000591446.7
    Conserved Domains (1) summary
    cd01804
    Location:31100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins
  4. NM_177401.5NP_796375.3  midnolin isoform 2

    See identical proteins and their annotated locations for NP_796375.3

    Status: VALIDATED

    Source sequence(s)
    AA421908, AL512725, BC015089, BC060848, BM966744
    Consensus CDS
    CCDS32864.1
    UniProtKB/Swiss-Prot
    Q504T8, Q96BW8
    Related
    ENSP00000300952.2, ENST00000300952.7
    Conserved Domains (1) summary
    cd01804
    Location:31100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1248583..1259143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259672.4XP_005259729.1  midnolin isoform X1

    Conserved Domains (1) summary
    cd01804
    Location:31100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1217106..1227667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322499.1XP_054178474.1  midnolin isoform X1

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