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Fzr1 fizzy and cell division cycle 20 related 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314642, updated on 4-Jan-2025

Summary

Official Symbol
Fzr1provided by RGD
Official Full Name
fizzy and cell division cycle 20 related 1provided by RGD
Primary source
RGD:1308713
See related
EnsemblRapid:ENSRNOG00000004169 AllianceGenome:RGD:1308713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdh1
Summary
Predicted to enable anaphase-promoting complex binding activity; ubiquitin ligase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; negative regulation of cell cycle process; and positive regulation of protein metabolic process. Predicted to act upstream of or within lens fiber cell differentiation; proteolysis involved in protein catabolic process; and regulation of meiotic nuclear division. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 118.8), Testes (RPKM 66.3) and 9 other tissues See more
Orthologs
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Genomic context

See Fzr1 in Genome Data Viewer
Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8982765..8994689)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8332029..8343953)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11201690..11213614)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 44 Neighboring gene deoxyhypusine hydroxylase Neighboring gene tektin bundle interacting protein 1 Neighboring gene major facilitator superfamily domain containing 12 Neighboring gene high mobility group 20 B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables anaphase-promoting complex binding  
enables protein binding PubMed 
enables ubiquitin ligase activator activity  
enables ubiquitin-like ligase-substrate adaptor activity  
Component Evidence Code Pubs
part_of anaphase-promoting complex  
located_in nuclear membrane  
located_in nuclear membrane  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  

General protein information

Preferred Names
fizzy-related protein homolog
Names
fizzy/cell division cycle 20 related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108074.2NP_001101544.2  fizzy-related protein homolog

    See identical proteins and their annotated locations for NP_001101544.2

    Status: PROVISIONAL

    Source sequence(s)
    BC162059
    UniProtKB/TrEMBL
    A0A8I5ZWS1, B1WCA1, F7EFQ4
    Related
    ENSRNOP00000005624.6, ENSRNOT00000005624.7
    Conserved Domains (2) summary
    cd00200
    Location:193471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232269
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8982765..8994689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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