U.S. flag

An official website of the United States government

Nrgn neurogranin [ Rattus norvegicus (Norway rat) ]

Gene ID: 64356, updated on 4-Jan-2025

Summary

Official Symbol
Nrgnprovided by RGD
Official Full Name
neurograninprovided by RGD
Primary source
RGD:61833
See related
EnsemblRapid:ENSRNOG00000010688 AllianceGenome:RGD:61833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RC3; BICKS
Summary
Enables calmodulin binding activity; phosphatidic acid binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in associative learning; modulation of chemical synaptic transmission; and telencephalon development. Located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of hypothyroidism and visual epilepsy. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 451.7), Lung (RPKM 23.7) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nrgn in Genome Data Viewer
Location:
8q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45444223..45452417, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37255462..37263659, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (40015049..40023193, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene endothelial cell adhesion molecule Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene uncharacterized LOC103693043 Neighboring gene uncharacterized LOC108351844

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in axon PubMed 
located_in cytosol  
located_in dendrite PubMed 
located_in dendritic spine head PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in mitochondrial membrane PubMed 
located_in neuronal cell body PubMed 
is_active_in postsynapse PubMed 
is_active_in postsynaptic membrane PubMed 
located_in trans-Golgi network transport vesicle membrane PubMed 

General protein information

Preferred Names
neurogranin
Names
neurogranin (protein kinase C substrate, RC3)
ng
protein kinase C substrate 7.5 kDa protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024140.3 → NP_077054.1  neurogranin

    See identical proteins and their annotated locations for NP_077054.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q04940
    UniProtKB/TrEMBL
    A0A8L2UIU9
    Related
    ENSRNOP00000014404.4, ENSRNOT00000014404.5
    Conserved Domains (1) summary
    smart00015
    Location:32 → 47
    IQ; Calmodulin-binding motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    45444223..45452417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.