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    Phax phosphorylated adaptor for RNA export [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286917, updated on 4-Jan-2025

    Summary

    Official Symbol
    Phaxprovided by RGD
    Official Full Name
    phosphorylated adaptor for RNA exportprovided by RGD
    Primary source
    RGD:708448
    See related
    EnsemblRapid:ENSRNOG00000014459 AllianceGenome:RGD:708448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnuxa
    Summary
    Enables toxic substance binding activity. Predicted to be involved in RNA stabilization and snRNA export from nucleus. Located in neuronal cell body. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 137.9), Brain (RPKM 132.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Phax in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (52251231..52267916)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (50053133..50069823)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (51662294..51678981)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1, pseudogene 11 Neighboring gene aldehyde dehydrogenase 7 family, member A1 Neighboring gene sperm microtubule inner protein 10 Neighboring gene uncharacterized LOC134483028 Neighboring gene uncharacterized LOC120098251

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA cap binding complex binding  
    enables toxic substance binding PubMed 
    Process Evidence Code Pubs
    involved_in RNA stabilization  
    involved_in protein transport  
    involved_in snRNA export from nucleus  
    involved_in snRNA export from nucleus  
    acts_upstream_of_or_within snRNA export from nucleus  
    Component Evidence Code Pubs
    located_in Cajal body  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    phosphorylated adapter RNA export protein
    Names
    26 kDa resiniferatoxin-binding protein
    RBP-2
    RBP-26
    RNA U small nuclear RNA export adapter protein
    RNA U, small nuclear RNA export adaptor
    RTX-42
    cytosolic resiniferatoxin-binding protein
    resiniferatoxin-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173133.2NP_775156.2  phosphorylated adapter RNA export protein

      See identical proteins and their annotated locations for NP_775156.2

      Status: VALIDATED

      Source sequence(s)
      AI044239, BC097932, CB706455
      UniProtKB/Swiss-Prot
      Q4QQW9, Q5RJZ7, Q63068
      UniProtKB/TrEMBL
      A6IX63, A6IX64
      Related
      ENSRNOP00000019627.4, ENSRNOT00000019627.6
      Conserved Domains (1) summary
      pfam10258
      Location:221304
      RNA_GG_bind; PHAX RNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      52251231..52267916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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