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F3 coagulation factor III, tissue factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25584, updated on 4-Jan-2025

Summary

Official Symbol
F3provided by RGD
Official Full Name
coagulation factor III, tissue factorprovided by RGD
Primary source
RGD:2587
See related
EnsemblRapid:ENSRNOG00000011800 AllianceGenome:RGD:2587
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TF
Summary
Enables protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Uterus (RPKM 286.8), Kidney (RPKM 217.8) and 8 other tissues See more
Orthologs
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Genomic context

Location:
2q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (212511675..212523375)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209827061..209838666)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (225310686..225322281)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554786 Neighboring gene uncharacterized LOC102555482 Neighboring gene uncharacterized LOC134485958 Neighboring gene ATP binding cassette subfamily D member 3 Neighboring gene uncharacterized LOC108350099

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC93621

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity  
enables phospholipid binding  
enables protease binding PubMed 
enables protease binding  
contributes_to serine-type endopeptidase activity  
Process Evidence Code Pubs
involved_in activation of plasma proteins involved in acute inflammatory response  
involved_in blood coagulation  
involved_in blood coagulation  
involved_in cellular response to hydrogen peroxide PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus PubMed 
involved_in cytokine-mediated signaling pathway  
involved_in positive regulation of TOR signaling  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of endothelial cell apoptotic process  
involved_in positive regulation of endothelial cell proliferation  
acts_upstream_of_or_within positive regulation of gene expression  
acts_upstream_of_or_within positive regulation of interleukin-8 production  
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway  
involved_in positive regulation of smooth muscle cell migration PubMed 
involved_in protein processing  
involved_in response to estradiol PubMed 
involved_in response to fluid shear stress PubMed 
involved_in response to lipopolysaccharide PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to temperature stimulus PubMed 
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in cell surface  
located_in collagen-containing extracellular matrix  
located_in extracellular space PubMed 
located_in extracellular space  
located_in membrane  
is_active_in plasma membrane  
part_of serine-type peptidase complex  

General protein information

Preferred Names
tissue factor
Names
coagulation factor 3
coagulation factor III (thromboplastin, tissue factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013057.2NP_037189.2  tissue factor precursor

    See identical proteins and their annotated locations for NP_037189.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081846
    UniProtKB/Swiss-Prot
    P42533
    UniProtKB/TrEMBL
    Q66HI4
    Related
    ENSRNOP00000015836.5, ENSRNOT00000015836.7
    Conserved Domains (2) summary
    pfam01108
    Location:17111
    Tissue_fac; Tissue factor
    pfam09294
    Location:139246
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    212511675..212523375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281370.1XP_063137440.1  tissue factor isoform X1

    UniProtKB/Swiss-Prot
    P42533
    UniProtKB/TrEMBL
    A0A8I5ZJL3
  2. XM_039101800.2XP_038957728.1  tissue factor isoform X3

    UniProtKB/TrEMBL
    F7EW83
    Conserved Domains (2) summary
    pfam09294
    Location:118225
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:185
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_063281371.1XP_063137441.1  tissue factor isoform X2

    Related
    ENSRNOP00000077841.2, ENSRNOT00000114365.2
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