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Anapc1 anaphase promoting complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 17222, updated on 4-Jan-2025

Summary

Official Symbol
Anapc1provided by MGI
Official Full Name
anaphase promoting complex subunit 1provided by MGI
Primary source
MGI:MGI:103097
See related
Ensembl:ENSMUSG00000014355 AllianceGenome:MGI:103097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apc1; Mcpr; tsg24; 2610021O03Rik
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein polyubiquitination. Located in nucleus. Is expressed in brain; cerebellum; and cerebral cortex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.6), limb E14.5 (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Anapc1 in Genome Data Viewer
Location:
2 F1; 2 62.63 cM
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128452003..128529558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128610083..128687406, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene predicted gene, 39929 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4498 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene transmembrane protein 87B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process  
involved_in anaphase-promoting complex-dependent catabolic process  
involved_in anaphase-promoting complex-dependent catabolic process  
involved_in cell division  
involved_in metaphase/anaphase transition of mitotic cell cycle  
involved_in protein K11-linked ubiquitination  
involved_in protein K11-linked ubiquitination  
involved_in protein K11-linked ubiquitination  
involved_in protein K48-linked ubiquitination  
involved_in protein K48-linked ubiquitination  
involved_in protein branched polyubiquitination  
Component Evidence Code Pubs
part_of anaphase-promoting complex  
part_of anaphase-promoting complex  
part_of anaphase-promoting complex  
located_in nucleus PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 1
Names
cyclosome subunit 1
meiotic check point regulator
mitotic checkpoint regulator
testis-specific gene 24 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008569.2NP_032595.2  anaphase-promoting complex subunit 1

    See identical proteins and their annotated locations for NP_032595.2

    Status: VALIDATED

    Source sequence(s)
    AK034858, AK077847, BB676785, BC139002, BE987509
    Consensus CDS
    CCDS16715.1
    UniProtKB/Swiss-Prot
    A2ATQ4, P53995, Q8BP33, Q8C772
    UniProtKB/TrEMBL
    B7ZNX2
    Related
    ENSMUSP00000014499.4, ENSMUST00000014499.10
    Conserved Domains (2) summary
    pfam01851
    Location:14671501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150218
    ANAPC1; Anaphase-promoting complex subunit 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    128452003..128529558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248086.2XP_030103946.1  anaphase-promoting complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    B7ZNX2
    Conserved Domains (2) summary
    pfam01851
    Location:13491383
    PC_rep; Proteasome/cyclosome repeat
    pfam18122
    Location:16181777
    APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain
  2. XM_011239332.4XP_011237634.1  anaphase-promoting complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A2ATQ5
    Related
    ENSMUSP00000105962.2, ENSMUST00000110333.2
    Conserved Domains (1) summary
    pfam12859
    Location:150218
    ANAPC1; Anaphase-promoting complex subunit 1

RNA

  1. XR_004938638.1 RNA Sequence

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