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P2RY6 pyrimidinergic receptor P2Y6 [ Homo sapiens (human) ]

Gene ID: 5031, updated on 4-Jan-2025

Summary

Official Symbol
P2RY6provided by HGNC
Official Full Name
pyrimidinergic receptor P2Y6provided by HGNC
Primary source
HGNC:HGNC:8543
See related
Ensembl:ENSG00000171631 MIM:602451; AllianceGenome:HGNC:8543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y6
Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
Expression
Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues See more
Orthologs
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Genomic context

See P2RY6 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73264506..73298625)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73193675..73227786)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72975551..73009670)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:72959838-72961037 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72975095-72975632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72981035-72981828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72981829-72982621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73000363-73000929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3737 Neighboring gene ARHGEF17 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73019433-73020310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73020316-73021136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5234 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73031799-73032452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73032453-73033105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73033106-73033758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73036372-73037023 Neighboring gene Sharpr-MPRA regulatory region 2623 Neighboring gene uncharacterized LOC124902710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73044313-73045026

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC15335

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in cellular response to prostaglandin E stimulus  
involved_in cellular response to purine-containing compound PubMed 
involved_in cellular response to pyrimidine ribonucleotide  
involved_in cellular response to pyrimidine ribonucleotide PubMed 
involved_in cellular response to pyrimidine ribonucleotide  
involved_in phagocytosis  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of inositol trisphosphate biosynthetic process PubMed 
involved_in positive regulation of inositol trisphosphate biosynthetic process PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of vascular associated smooth muscle cell proliferation PubMed 
involved_in transepithelial chloride transport  
Component Evidence Code Pubs
located_in apical plasma membrane  
located_in basolateral plasma membrane  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
P2Y purinoceptor 6
Names
G-coupled nucleotide receptor
P2 purinoceptor
P2Y6 receptor
pyrimidinergic receptor P2Y, G-protein coupled, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277204.2NP_001264133.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF218005, BC009391, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000442551.1, ENST00000540124.6
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001277205.2NP_001264134.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AL525099, BC009391, BX397649, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000445652.1, ENST00000542092.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001277206.2NP_001264135.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AP002761, BC009391, BQ718871, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000480966.1, ENST00000618468.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001277207.2NP_001264136.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AP002761, BC009391, BX337204, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000504879.1, ENST00000679753.1
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001277208.1NP_001264137.1  P2Y purinoceptor 6 isoform 2

    See identical proteins and their annotated locations for NP_001264137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate 5'-most exon and initiates translation at an alternate start codon so that the 5' UTR and 5' coding region differ compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    BC009391, DR004482, HY271000
    UniProtKB/Swiss-Prot
    Q15077
    Conserved Domains (1) summary
    pfam00001
    Location:145401
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. NM_176796.3NP_789766.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_789766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    BC009391, BX381745, BX397649, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000309771.2, ENST00000349767.6
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_176797.3NP_789767.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_789767.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF007891, BC009391, BX397649, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000377217.2, ENST00000393592.7
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_176798.2NP_789768.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_789768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF007892, BC009391, DR006998, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000377216.1, ENST00000393591.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    73264506..73298625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545079.3XP_011543381.1  P2Y purinoceptor 6 isoform X3

    See identical proteins and their annotated locations for XP_011543381.1

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000443427.1, ENST00000540342.6
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_047427038.1XP_047282994.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  3. XM_011545076.3XP_011543378.1  P2Y purinoceptor 6 isoform X1

    UniProtKB/TrEMBL
    A0A7P0TA46
    Conserved Domains (1) summary
    pfam00001
    Location:114370
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_047427036.1XP_047282992.1  P2Y purinoceptor 6 isoform X2

    UniProtKB/TrEMBL
    A0A7P0TA46
  5. XM_047427037.1XP_047282993.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  6. XM_047427039.1XP_047282995.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  7. XM_006718571.4XP_006718634.1  P2Y purinoceptor 6 isoform X3

    See identical proteins and their annotated locations for XP_006718634.1

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000442990.1, ENST00000538328.2
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. XM_005274022.4XP_005274079.1  P2Y purinoceptor 6 isoform X3

    See identical proteins and their annotated locations for XP_005274079.1

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
    Related
    ENSP00000505646.1, ENST00000680955.1
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    73193675..73227786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369000.1XP_054224975.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  2. XM_054368998.1XP_054224973.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  3. XM_054368994.1XP_054224969.1  P2Y purinoceptor 6 isoform X1

    UniProtKB/TrEMBL
    A0A7P0TA46
  4. XM_054368995.1XP_054224970.1  P2Y purinoceptor 6 isoform X2

    UniProtKB/TrEMBL
    A0A7P0TA46
  5. XM_054368997.1XP_054224972.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  6. XM_054369001.1XP_054224976.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  7. XM_054368996.1XP_054224971.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46
  8. XM_054368999.1XP_054224974.1  P2Y purinoceptor 6 isoform X3

    UniProtKB/Swiss-Prot
    Q15077, Q15754
    UniProtKB/TrEMBL
    A0A7P0TA46

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