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Casp6 caspase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83584, updated on 4-Jan-2025

Summary

Symbol
Casp6provided by RGD
Full Name
caspase 6provided by RGD
Primary source
RGD:70967
See related
EnsemblRapid:ENSRNOG00000052613 AllianceGenome:RGD:70967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mch2
Summary
Enables endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Located in axon and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 132.6), Liver (RPKM 128.0) and 9 other tissues See more
Orthologs
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Genomic context

See Casp6 in Genome Data Viewer
Location:
2q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (221140287..221152727)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (218466063..218478503)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (235341326..235353715)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene complement factor I Neighboring gene uncharacterized LOC120100942 Neighboring gene phospholipase A2, group XIIA Neighboring gene uncharacterized LOC134485965 Neighboring gene mitochondrial calcium uniporter dominant negative subunit beta Neighboring gene SEC24 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC93335

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity  
enables cysteine-type endopeptidase activity  
enables cysteine-type endopeptidase activity  
enables cysteine-type endopeptidase activity  
enables endopeptidase activity PubMed 
enables endopeptidase activity  
enables identical protein binding  
enables identical protein binding  
Items 1 - 25 of 44
Process Evidence Code Pubs
involved_in activation of innate immune response  
involved_in activation of innate immune response  
involved_in activation of innate immune response  
involved_in acute inflammatory response to non-antigenic stimulus PubMed 
involved_in apoptotic process  
involved_in axonal fasciculation PubMed 
involved_in cellular response to staurosporine  
involved_in cellular response to staurosporine  
involved_in epithelial cell differentiation  
involved_in epithelial cell differentiation  
involved_in hepatocyte apoptotic process  
involved_in hepatocyte apoptotic process  
involved_in hepatocyte apoptotic process  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
involved_in lens development in camera-type eye PubMed 
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of necroptotic process  
involved_in positive regulation of necroptotic process  
involved_in positive regulation of necroptotic process  
involved_in positive regulation of neuron apoptotic process  
involved_in positive regulation of neuron apoptotic process PubMed 
involved_in positive regulation of retinal cell programmed cell death PubMed 
involved_in protein autoprocessing  
involved_in protein autoprocessing  
involved_in protein autoprocessing  
involved_in proteolysis  
involved_in pyroptotic inflammatory response  
involved_in pyroptotic inflammatory response  
involved_in pyroptotic inflammatory response  
involved_in regulation of programmed cell death  
involved_in response to cytokine PubMed 
involved_in response to estradiol PubMed 
involved_in response to gamma radiation PubMed 
involved_in response to glucose PubMed 
involved_in response to hydrogen peroxide PubMed 
involved_in response to iron ion PubMed 
involved_in response to metal ion PubMed 
involved_in response to testosterone PubMed 
involved_in response to toxic substance PubMed 
Items 1 - 25 of 44
Component Evidence Code Pubs
located_in axon PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in neuronal cell body PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  

General protein information

Preferred Names
caspase-6
Names
CASP-6
apoptotic protease Mch-2
NP_001258913.1
NP_113963.2
XP_017446624.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271984.1NP_001258913.1  caspase-6

    See identical proteins and their annotated locations for NP_001258913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078785, DY310578, FM068086
    UniProtKB/Swiss-Prot
    O35397
    UniProtKB/TrEMBL
    Q6AZ23
    Conserved Domains (1) summary
    smart00115
    Location:20273
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  2. NM_031775.3NP_113963.2  caspase-6

    See identical proteins and their annotated locations for NP_113963.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078785, FM068086
    UniProtKB/Swiss-Prot
    O35397
    UniProtKB/TrEMBL
    Q6AZ23
    Conserved Domains (1) summary
    smart00115
    Location:20273
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    221140287..221152727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591135.2XP_017446624.1  caspase-6 isoform X1

    UniProtKB/Swiss-Prot
    O35397
    UniProtKB/TrEMBL
    F6Q5I5
    Related
    ENSRNOP00000013049.4, ENSRNOT00000013049.8
    Conserved Domains (1) summary
    smart00115
    Location:19272
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
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