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MYO9B myosin IXB [ Homo sapiens (human) ]

Gene ID: 4650, updated on 11-Jan-2025

Summary

Official Symbol
MYO9Bprovided by HGNC
Official Full Name
myosin IXBprovided by HGNC
Primary source
HGNC:HGNC:7609
See related
Ensembl:ENSG00000099331 MIM:602129; AllianceGenome:HGNC:7609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYR5; CELIAC4
Summary
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in spleen (RPKM 30.6), bone marrow (RPKM 21.4) and 24 other tissues See more
Orthologs
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Genomic context

See MYO9B in Genome Data Viewer
Location:
19p13.11
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17075777..17213286)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17210700..17348159)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17186587..17324095)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene C3 and PZP like alpha-2-macroglobulin domain containing 8 Neighboring gene RNA, 7SL, cytoplasmic 823, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17062521-17063084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17071591-17072150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17072151-17072708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17137792-17138700 Neighboring gene Sharpr-MPRA regulatory region 9643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10319 Neighboring gene Sharpr-MPRA regulatory region 7940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17190569-17191106 Neighboring gene HAUS augmin like complex subunit 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17192643-17193192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17221215-17221716 Neighboring gene small nucleolar RNA, H/ACA box 118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17227113-17227612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17241751-17242749 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17245802-17246410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17245192-17245801 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17246411-17247020 Neighboring gene Sharpr-MPRA regulatory region 10590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17260531-17261223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:17263413-17264160 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17269991-17270808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17270809-17271626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17271627-17272442 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17288573-17288756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17291382-17291974 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:17291975-17292566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17321117-17321622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:17325806-17326386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17336955-17337629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17337630-17338303 Neighboring gene unconventional SNARE in the ER 1 Neighboring gene occludin/ELL domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
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EBI GWAS Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding PubMed 
enables ATP binding  
enables ATP binding PubMed 
enables ATP hydrolysis activity  
enables GTPase activator activity PubMed 
enables GTPase activator activity  
enables Roundabout binding PubMed 
enables actin binding PubMed 
enables actin filament binding  
enables calmodulin binding PubMed 
enables metal ion binding  
enables microfilament motor activity  
enables microfilament motor activity PubMed 
enables protein binding PubMed 
NOT enables protein homodimerization activity PubMed 
enables small GTPase binding PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton PubMed 
is_active_in actin filament  
located_in actin filament PubMed 
located_in cell cortex PubMed 
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
is_active_in lamellipodium  
located_in membrane PubMed 
part_of myosin complex  
located_in perinuclear region of cytoplasm PubMed 
is_active_in postsynaptic actin cytoskeleton PubMed 
is_active_in postsynaptic actin cytoskeleton PubMed 
is_active_in ruffle  

General protein information

Preferred Names
unconventional myosin-IXb
Names
myosin-IXb
unconventional myosin-9b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013068.2 RefSeqGene

    Range
    5002..142511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130065.2NP_001123537.1  unconventional myosin-IXb isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region due to the use of an alternate splice site in the penultimate exon. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB209997, AC020908, BC018108, BF905466, BI001923, BI827217, CN284963, DR006748
    Consensus CDS
    CCDS46010.1
    UniProtKB/TrEMBL
    Q4LE74
    Related
    ENSP00000471457.1, ENST00000595618.5
    Conserved Domains (6) summary
    cd01779
    Location:7112
    Myosin_IXb_RA; ubitquitin-like domain of Myosin_IXb_RA
    smart00015
    Location:10001022
    IQ; Calmodulin-binding motif
    smart00242
    Location:141950
    MYSc; Myosin. Large ATPases
    cd00029
    Location:16331681
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04407
    Location:16981883
    RhoGAP_myosin_IXB; RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160941
    MYSc_Myo9; class IX myosin, motor domain
  2. NM_004145.4NP_004136.2  unconventional myosin-IXb isoform 1

    See identical proteins and their annotated locations for NP_004136.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB290184, AC020908, BC018108, BF905466, BI001923, BI827217, CN284963, DR006748
    Consensus CDS
    CCDS92551.1
    UniProtKB/Swiss-Prot
    O75314, Q13459, Q9NUJ2, Q9UHN0
    UniProtKB/TrEMBL
    B0I1T6, M0R0P8
    Related
    ENSP00000507803.1, ENST00000682292.1
    Conserved Domains (6) summary
    cd01779
    Location:7112
    Myosin_IXb_RA; ubitquitin-like domain of Myosin_IXb_RA
    smart00015
    Location:10001022
    IQ; Calmodulin-binding motif
    smart00242
    Location:141950
    MYSc; Myosin. Large ATPases
    cd00029
    Location:16331681
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04407
    Location:16981883
    RhoGAP_myosin_IXB; RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a ...
    cd01385
    Location:160941
    MYSc_Myo9; class IX myosin, motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    17075777..17213286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    17210700..17348159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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