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Traf2 Tnf receptor-associated factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311786, updated on 4-Jan-2025

Summary

Official Symbol
Traf2provided by RGD
Official Full Name
Tnf receptor-associated factor 2provided by RGD
Primary source
RGD:1310457
See related
EnsemblRapid:ENSRNOG00000006238 AllianceGenome:RGD:1310457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex. Part of protein-containing complex. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 176.1), Testes (RPKM 148.2) and 9 other tissues See more
Orthologs
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Genomic context

See Traf2 in Genome Data Viewer
Location:
3p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28740098..28764752, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8341950..8366609, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2746061..2770690, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene complement C8 gamma chain Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene endothelial differentiation-related factor 1 Neighboring gene MAM domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CD40 receptor binding  
enables enzyme binding  
enables identical protein binding  
enables mitogen-activated protein kinase kinase kinase binding PubMed 
enables protein binding PubMed 
enables protein kinase binding PubMed 
enables protein kinase binding  
enables protein phosphatase binding  
enables protein-containing complex binding PubMed 
enables protein-containing complex binding  
enables protein-macromolecule adaptor activity  
enables signaling adaptor activity  
enables signaling adaptor activity  
enables sphingolipid binding  
enables thioesterase binding  
enables tumor necrosis factor binding  
enables tumor necrosis factor receptor binding  
enables tumor necrosis factor receptor binding  
enables ubiquitin protein ligase activity  
enables ubiquitin protein ligase binding  
enables ubiquitin-protein transferase activity  
enables ubiquitin-protein transferase activity  
enables zinc ion binding  
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in CD27 signaling pathway  
involved_in CD40 signaling pathway  
involved_in T cell activation  
involved_in TORC1 complex assembly  
involved_in TORC2 complex disassembly  
acts_upstream_of_or_within cellular response to nitric oxide  
acts_upstream_of_positive_effect innate immune response  
involved_in interleukin-17-mediated signaling pathway  
involved_in mRNA stabilization  
involved_in negative regulation of glial cell apoptotic process PubMed 
involved_in non-canonical NF-kappaB signal transduction  
involved_in positive regulation of DNA-binding transcription factor activity  
involved_in positive regulation of JUN kinase activity  
involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in positive regulation of T cell cytokine production  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of extrinsic apoptotic signaling pathway  
involved_in positive regulation of interleukin-2 production  
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway  
acts_upstream_of_or_within programmed necrotic cell death  
involved_in protein K63-linked ubiquitination  
involved_in protein autoubiquitination  
acts_upstream_of_or_within protein catabolic process  
involved_in protein-containing complex assembly  
acts_upstream_of_or_within regulation of JNK cascade  
involved_in regulation of apoptotic process  
acts_upstream_of_or_within regulation of immunoglobulin production  
involved_in regulation of protein-containing complex assembly  
acts_upstream_of_or_within signal transduction  
involved_in signal transduction involved in regulation of gene expression  
involved_in tumor necrosis factor-mediated signaling pathway  
involved_in tumor necrosis factor-mediated signaling pathway PubMed 
involved_in tumor necrosis factor-mediated signaling pathway  
Items 1 - 25 of 35
Component Evidence Code Pubs
part_of CD40 receptor complex  
part_of IRE1-TRAF2-ASK1 complex  
part_of IRE1-TRAF2-ASK1 complex  
part_of TRAF2-GSTP1 complex  
located_in cell cortex PubMed 
is_active_in cytoplasm  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasmic side of plasma membrane  
located_in cytosol  
located_in membrane raft  
part_of plasma membrane signaling receptor complex  
part_of protein-containing complex PubMed 
part_of tumor necrosis factor receptor superfamily complex  
part_of ubiquitin ligase complex  
located_in vesicle membrane  

General protein information

Preferred Names
TNF receptor-associated factor 2
NP_001101285.1
XP_006233656.1
XP_006233658.1
XP_008759810.1
XP_038961110.1
XP_038961111.1
XP_063139987.1
XP_063139988.1
XP_063139989.1
XP_063139990.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107815.2NP_001101285.1  TNF receptor-associated factor 2

    See identical proteins and their annotated locations for NP_001101285.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169064
    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
    Conserved Domains (4) summary
    cd03778
    Location:330493
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178234
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:265325
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28740098..28764752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233596.5XP_006233658.1  TNF receptor-associated factor 2 isoform X2

    Conserved Domains (4) summary
    cd03778
    Location:276439
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:124180
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:211271
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  2. XM_063283919.1XP_063139989.1  TNF receptor-associated factor 2 isoform X2

  3. XM_006233594.5XP_006233656.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006233656.1

    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
    Conserved Domains (4) summary
    cd03778
    Location:330493
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178234
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:265325
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  4. XM_063283920.1XP_063139990.1  TNF receptor-associated factor 2 isoform X2

  5. XM_008761588.4XP_008759810.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_008759810.1

    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
    Related
    ENSRNOP00000008253.7, ENSRNOT00000008253.8
    Conserved Domains (4) summary
    cd03778
    Location:330493
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178234
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:265325
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  6. XM_063283918.1XP_063139988.1  TNF receptor-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
  7. XM_039105182.2XP_038961110.1  TNF receptor-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
    Conserved Domains (4) summary
    cd03778
    Location:330493
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178234
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:265325
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  8. XM_039105183.2XP_038961111.1  TNF receptor-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
    Conserved Domains (4) summary
    cd03778
    Location:330493
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178234
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:265325
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  9. XM_063283917.1XP_063139987.1  TNF receptor-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y7P7, B5DFH7, E9PSP4
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