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NCBI Reference Sequence: NP_001100035.1
Identical Proteins FASTA Graphics
LOCUS NP_001100035 311 aa linear ROD 22-MAR-2023 DEFINITION mediator of RNA polymerase II transcription subunit 27 [Rattus norvegicus]. ACCESSION NP_001100035 XP_001076126 XP_216025 VERSION NP_001100035.1 DBSOURCE REFSEQ: accession NM_001106565.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 311) AUTHORS Poss ZC, Ebmeier CC and Taatjes DJ. TITLE The Mediator complex and transcription regulation JOURNAL Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013) PUBMED 24088064 REMARK Review article REFERENCE 2 (residues 1 to 311) AUTHORS Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J and Young RA. TITLE Mediator and cohesin connect gene expression and chromatin architecture JOURNAL Nature 467 (7314), 430-435 (2010) PUBMED 20720539 REMARK Erratum:[Nature. 2011 Apr 14;472(7342):247] REFERENCE 3 (residues 1 to 311) AUTHORS Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC and Tora L. TITLE ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes JOURNAL EMBO Rep 11 (7), 541-547 (2010) PUBMED 20508642 REFERENCE 4 (residues 1 to 311) AUTHORS Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW and Conaway RC. TITLE Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase JOURNAL Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002) PUBMED 12149480 REFERENCE 5 (residues 1 to 311) AUTHORS Malik S, Gu W, Wu W, Qin J and Roeder RG. TITLE The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs JOURNAL Mol Cell 5 (4), 753-760 (2000) PUBMED 10882111 REFERENCE 6 (residues 1 to 311) AUTHORS Ryu S, Zhou S, Ladurner AG and Tjian R. TITLE The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 JOURNAL Nature 397 (6718), 446-450 (1999) PUBMED 9989412 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474001.2. On or before Oct 4, 2007 this sequence version replaced XP_001076126.1, XP_216025.3. ##Evidence-Data-START## Transcript exon combination :: BC167032.1, EV772276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..311 /organism="Rattus norvegicus" /db_xref="taxon:10116" /chromosome="3" /map="3p12" Protein 1..311 /product="mediator of RNA polymerase II transcription subunit 27" /calculated_mol_wt=35158 Region 228..309 /region_name="Med27" /note="Mediator complex subunit 27; pfam11571" /db_xref="CDD:463298" CDS 1..311 /gene="Med27" /gene_synonym="RGD1564993" /coded_by="NM_001106565.1:48..983" /db_xref="GeneID:296612" /db_xref="RGD:1564993" ORIGIN 1 madvlsvgvn leafsqaisa iqalrssvsr vfdclkdgmr nketlegrek afiahfqdnl 61 hsvnrdlnel erlsnlvgkp senhplhnsg llsldpvqdk tplysqllqa ykwsnklqyh 121 aglasgllnq qslkrsanqm gvsakrrpka qpttlvlppq yvddvisrid rmfpemsihl 181 srpngtsavl lvtlgkvlkv ivvmrslfid rtivkgynes vytedgkldi wskssyqvfq 241 kvtdhattal lhyqlpqmpd vvvrsfmtwl rsyiklfqap cqrcgkflqd glpptwrdfr 301 tleafhdtcr q //
Whole sequence Selected region from: to:
Conserved Domains
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