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integrin beta-2 precursor [Rattus norvegicus]

NCBI Reference Sequence: NP_001032869.2

Identical Proteins FASTA Graphics 

LOCUS       NP_001032869             768 aa            linear   ROD 26-FEB-2024
DEFINITION  integrin beta-2 precursor [Rattus norvegicus].
ACCESSION   NP_001032869 XP_228072
VERSION     NP_001032869.2
DBSOURCE    REFSEQ: accession NM_001037780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 768)
  AUTHORS   Zhou H, Yang Z, Mu L and Shi Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 768)
  AUTHORS   Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZS, Zeng L,
            Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT,
            Soberman RJ and Nigrovic PA.
  TITLE     CD177 modulates human neutrophil migration through
            activation-mediated integrin and chemoreceptor regulation
  JOURNAL   Blood 130 (19), 2092-2100 (2017)
   PUBMED   28807980
REFERENCE   3  (residues 1 to 768)
  AUTHORS   Oksala N, Parssinen J, Seppala I, Klopp N, Illig T, Laaksonen R,
            Levula M, Raitoharju E, Kholova I, Sioris T, Kahonen M, Lehtimaki T
            and Hytonen VP.
  TITLE     Kindlin 3 (FERMT3) is associated with unstable atherosclerotic
            plaques, anti-inflammatory type II macrophages and upregulation of
            beta-2 integrins in all major arterial beds
  JOURNAL   Atherosclerosis 242 (1), 145-154 (2015)
   PUBMED   26188538
REFERENCE   4  (residues 1 to 768)
  AUTHORS   Baert K, Sonck E, Goddeeris BM, Devriendt B and Cox E.
  TITLE     Cell type-specific differences in beta-glucan recognition and
            signalling in porcine innate immune cells
  JOURNAL   Dev Comp Immunol 48 (1), 192-203 (2015)
   PUBMED   25453580
REFERENCE   5  (residues 1 to 768)
  AUTHORS   Morales O, Mrizak D, Francois V, Mustapha R, Miroux C, Depil S,
            Decouvelaere AV, Lionne-Huyghe P, Auriault C, de Launoit Y, Pancre
            V and Delhem N.
  TITLE     Epstein-Barr virus infection induces an increase of T regulatory
            type 1 cells in Hodgkin lymphoma patients
  JOURNAL   Br J Haematol 166 (6), 875-890 (2014)
   PUBMED   25041527
REFERENCE   6  (residues 1 to 768)
  AUTHORS   Wada J, Shikata K, Makino H, Morioka S, Hirata K, Ota K, Tamatani
            T, Miyasaka M, Horiuchi T, Noji S, Nishikawa K, Myokai F, Taniguchi
            S, Kanwar Y and Ota Z.
  TITLE     The critical role of intercellular adhesion molecule-1 in Masugi
            nephritis in rats
  JOURNAL   Nephron 73 (2), 264-272 (1996)
   PUBMED   8773354
REFERENCE   7  (residues 1 to 768)
  AUTHORS   Chu HW, Wang JM, Boutet M, Boulet LP and Laviolette M.
  TITLE     Increased expression of intercellular adhesion molecule-1 (ICAM-1)
            in a murine model of pulmonary eosinophilia and high IgE level
  JOURNAL   Clin Exp Immunol 100 (2), 319-324 (1995)
   PUBMED   7743671
REFERENCE   8  (residues 1 to 768)
  AUTHORS   Mulligan MS, Warren JS, Smith CW, Anderson DC, Yeh CG, Rudolph AR
            and Ward PA.
  TITLE     Lung injury after deposition of IgA immune complexes. Requirements
            for CD18 and L-arginine
  JOURNAL   J Immunol 148 (10), 3086-3092 (1992)
   PUBMED   1374449
REFERENCE   9  (residues 1 to 768)
  AUTHORS   Tamatani T, Kotani M and Miyasaka M.
  TITLE     Characterization of the rat leukocyte integrin, CD11/CD18, by the
            use of LFA-1 subunit-specific monoclonal antibodies
  JOURNAL   Eur J Immunol 21 (3), 627-633 (1991)
   PUBMED   1672643
REFERENCE   10 (residues 1 to 768)
  AUTHORS   Arnaout MA, Dana N, Gupta SK, Tenen DG and Fathallah DM.
  TITLE     Point mutations impairing cell surface expression of the common
            beta subunit (CD18) in a patient with leukocyte adhesion molecule
            (Leu-CAM) deficiency
  JOURNAL   J Clin Invest 85 (3), 977-981 (1990)
   PUBMED   1968911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085817.1.
            
            On Dec 27, 2007 this sequence version replaced NP_001032869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132272,
                                           SAMD00132286 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..768
                     /product="integrin beta-2 precursor"
                     /note="integrin, beta 2 (antigen CD18 (p95), lymphocyte
                     function-associated antigen 1; macrophage antigen 1
                     (mac-1) beta subunit); CD18 leukocyte adhesion molecule;
                     integrin beta-2"
                     /calculated_mol_wt=82586
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2251
     Region          33..447
                     /region_name="INB"
                     /note="Integrin beta subunits (N-terminal portion of
                     extracellular region); smart00187"
                     /db_xref="CDD:197563"
     Region          622..698
                     /region_name="Integrin_B_tail"
                     /note="Integrin beta tail domain; pfam07965"
                     /db_xref="CDD:462325"
     Region          726..765
                     /region_name="Integrin_b_cyt"
                     /note="Integrin beta cytoplasmic domain; pfam08725"
                     /db_xref="CDD:462580"
     CDS             1..768
                     /gene="Itgb2"
                     /gene_synonym="Cd18"
                     /coded_by="NM_001037780.2:254..2560"
                     /db_xref="GeneID:309684"
                     /db_xref="RGD:1305581"
ORIGIN      
        1 mlgphtllli lagllflgsa lseectkykv sncrdciqsg pgcswcqkln ftgpgepdsl
       61 rcdtraqlll kgcpaddimd pksfadlhpq yqvqrsqlsp qkvtlnlrpg qaaafnvtfr
      121 rakgypidly ylmdlsysml ddlnnvkklg gdllqalnei tesgrigfgs fvdktvlpfv
      181 nthpeklrnp cpnkekacqp pfafrhvlkl tdnsnqfqte vgkqlisgnl dapeggldai
      241 mqvaacpeei gwrnvtrllv fatddgfhfa gdgklgailt pndgrchled nmykrsnefd
      301 ypsvgqlahk lsesniqpif avtkkmvkty eklteiipks avgelsddss nvvqlikkay
      361 yklssrvfld httipdtlkv tydsfcnnrv ssigksrgdc dgvqinnpvt fqvkvtasec
      421 iqeqsfvira lgftdtvtvq vhpqcecqcr dqsrmrnlcg gkgvmecgic rcesgyigkn
      481 cecqtqgrss qelegncrkd nssivcsglg dcicgqcvch tsdipnkvif gqycecdnfn
      541 cerydgqvcg glkrgscscg qcnckegfeg sacqcqrstt gclnarlvec sgrgrcqcnr
      601 cicekgyqpp lceecpgcpl pcstyvfcae clkfdkgpfq kncsvqcanv tlqtvpfkkk
      661 pckerdsegc witytlqqkd gnaynihvdd drecvkgpnv aaiiggtvag vvligvlllv
      721 iwkalthltd lneyrrfeke klksqwnndn plfksatttv mnpkfaes
//
Feature
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