LOCUS NP_001032869 768 aa linear ROD 26-FEB-2024
DEFINITION integrin beta-2 precursor [Rattus norvegicus].
ACCESSION NP_001032869 XP_228072
VERSION NP_001032869.2
DBSOURCE REFSEQ: accession NM_001037780.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 768)
AUTHORS Zhou H, Yang Z, Mu L and Shi Y.
TITLE Integrated Analysis of Multiple Microarray Studies to Identify Core
Gene-Expression Signatures Involved in Tubulointerstitial Injury in
Diabetic Nephropathy
JOURNAL Biomed Res Int 2022, 9554658 (2022)
PUBMED 35592524
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 768)
AUTHORS Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZS, Zeng L,
Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT,
Soberman RJ and Nigrovic PA.
TITLE CD177 modulates human neutrophil migration through
activation-mediated integrin and chemoreceptor regulation
JOURNAL Blood 130 (19), 2092-2100 (2017)
PUBMED 28807980
REFERENCE 3 (residues 1 to 768)
AUTHORS Oksala N, Parssinen J, Seppala I, Klopp N, Illig T, Laaksonen R,
Levula M, Raitoharju E, Kholova I, Sioris T, Kahonen M, Lehtimaki T
and Hytonen VP.
TITLE Kindlin 3 (FERMT3) is associated with unstable atherosclerotic
plaques, anti-inflammatory type II macrophages and upregulation of
beta-2 integrins in all major arterial beds
JOURNAL Atherosclerosis 242 (1), 145-154 (2015)
PUBMED 26188538
REFERENCE 4 (residues 1 to 768)
AUTHORS Baert K, Sonck E, Goddeeris BM, Devriendt B and Cox E.
TITLE Cell type-specific differences in beta-glucan recognition and
signalling in porcine innate immune cells
JOURNAL Dev Comp Immunol 48 (1), 192-203 (2015)
PUBMED 25453580
REFERENCE 5 (residues 1 to 768)
AUTHORS Morales O, Mrizak D, Francois V, Mustapha R, Miroux C, Depil S,
Decouvelaere AV, Lionne-Huyghe P, Auriault C, de Launoit Y, Pancre
V and Delhem N.
TITLE Epstein-Barr virus infection induces an increase of T regulatory
type 1 cells in Hodgkin lymphoma patients
JOURNAL Br J Haematol 166 (6), 875-890 (2014)
PUBMED 25041527
REFERENCE 6 (residues 1 to 768)
AUTHORS Wada J, Shikata K, Makino H, Morioka S, Hirata K, Ota K, Tamatani
T, Miyasaka M, Horiuchi T, Noji S, Nishikawa K, Myokai F, Taniguchi
S, Kanwar Y and Ota Z.
TITLE The critical role of intercellular adhesion molecule-1 in Masugi
nephritis in rats
JOURNAL Nephron 73 (2), 264-272 (1996)
PUBMED 8773354
REFERENCE 7 (residues 1 to 768)
AUTHORS Chu HW, Wang JM, Boutet M, Boulet LP and Laviolette M.
TITLE Increased expression of intercellular adhesion molecule-1 (ICAM-1)
in a murine model of pulmonary eosinophilia and high IgE level
JOURNAL Clin Exp Immunol 100 (2), 319-324 (1995)
PUBMED 7743671
REFERENCE 8 (residues 1 to 768)
AUTHORS Mulligan MS, Warren JS, Smith CW, Anderson DC, Yeh CG, Rudolph AR
and Ward PA.
TITLE Lung injury after deposition of IgA immune complexes. Requirements
for CD18 and L-arginine
JOURNAL J Immunol 148 (10), 3086-3092 (1992)
PUBMED 1374449
REFERENCE 9 (residues 1 to 768)
AUTHORS Tamatani T, Kotani M and Miyasaka M.
TITLE Characterization of the rat leukocyte integrin, CD11/CD18, by the
use of LFA-1 subunit-specific monoclonal antibodies
JOURNAL Eur J Immunol 21 (3), 627-633 (1991)
PUBMED 1672643
REFERENCE 10 (residues 1 to 768)
AUTHORS Arnaout MA, Dana N, Gupta SK, Tenen DG and Fathallah DM.
TITLE Point mutations impairing cell surface expression of the common
beta subunit (CD18) in a patient with leukocyte adhesion molecule
(Leu-CAM) deficiency
JOURNAL J Clin Invest 85 (3), 977-981 (1990)
PUBMED 1968911
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC085817.1.
On Dec 27, 2007 this sequence version replaced NP_001032869.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC166721.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMD00132272,
SAMD00132286 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..768
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="20"
/map="20p12"
Protein 1..768
/product="integrin beta-2 precursor"
/note="integrin, beta 2 (antigen CD18 (p95), lymphocyte
function-associated antigen 1; macrophage antigen 1
(mac-1) beta subunit); CD18 leukocyte adhesion molecule;
integrin beta-2"
/calculated_mol_wt=82586
sig_peptide 1..22
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2251
Region 33..447
/region_name="INB"
/note="Integrin beta subunits (N-terminal portion of
extracellular region); smart00187"
/db_xref="CDD:197563"
Region 622..698
/region_name="Integrin_B_tail"
/note="Integrin beta tail domain; pfam07965"
/db_xref="CDD:462325"
Region 726..765
/region_name="Integrin_b_cyt"
/note="Integrin beta cytoplasmic domain; pfam08725"
/db_xref="CDD:462580"
CDS 1..768
/gene="Itgb2"
/gene_synonym="Cd18"
/coded_by="NM_001037780.2:254..2560"
/db_xref="GeneID:309684"
/db_xref="RGD:1305581"
ORIGIN
1 mlgphtllli lagllflgsa lseectkykv sncrdciqsg pgcswcqkln ftgpgepdsl
61 rcdtraqlll kgcpaddimd pksfadlhpq yqvqrsqlsp qkvtlnlrpg qaaafnvtfr
121 rakgypidly ylmdlsysml ddlnnvkklg gdllqalnei tesgrigfgs fvdktvlpfv
181 nthpeklrnp cpnkekacqp pfafrhvlkl tdnsnqfqte vgkqlisgnl dapeggldai
241 mqvaacpeei gwrnvtrllv fatddgfhfa gdgklgailt pndgrchled nmykrsnefd
301 ypsvgqlahk lsesniqpif avtkkmvkty eklteiipks avgelsddss nvvqlikkay
361 yklssrvfld httipdtlkv tydsfcnnrv ssigksrgdc dgvqinnpvt fqvkvtasec
421 iqeqsfvira lgftdtvtvq vhpqcecqcr dqsrmrnlcg gkgvmecgic rcesgyigkn
481 cecqtqgrss qelegncrkd nssivcsglg dcicgqcvch tsdipnkvif gqycecdnfn
541 cerydgqvcg glkrgscscg qcnckegfeg sacqcqrstt gclnarlvec sgrgrcqcnr
601 cicekgyqpp lceecpgcpl pcstyvfcae clkfdkgpfq kncsvqcanv tlqtvpfkkk
661 pckerdsegc witytlqqkd gnaynihvdd drecvkgpnv aaiiggtvag vvligvlllv
721 iwkalthltd lneyrrfeke klksqwnndn plfksatttv mnpkfaes
//