U.S. flag

An official website of the United States government

prolyl endopeptidase FAP [Rattus norvegicus]

NCBI Reference Sequence: NP_620205.1

Identical Proteins FASTA Graphics 

LOCUS       NP_620205                761 aa            linear   ROD 26-FEB-2024
DEFINITION  prolyl endopeptidase FAP [Rattus norvegicus].
ACCESSION   NP_620205
VERSION     NP_620205.1
DBSOURCE    REFSEQ: accession NM_138850.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 761)
  AUTHORS   Kilvaer TK, Rakaee M, Hellevik T, Ostman A, Strell C, Bremnes RM,
            Busund LT, Donnem T and Martinez-Zubiaurre I.
  TITLE     Tissue analyses reveal a potential immune-adjuvant function of
            FAP-1 positive fibroblasts in non-small cell lung cancer
  JOURNAL   PLoS One 13 (2), e0192157 (2018)
   PUBMED   29415055
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 761)
  AUTHORS   Tillmanns J, Hoffmann D, Habbaba Y, Schmitto JD, Sedding D,
            Fraccarollo D, Galuppo P and Bauersachs J.
  TITLE     Fibroblast activation protein alpha expression identifies activated
            fibroblasts after myocardial infarction
  JOURNAL   J Mol Cell Cardiol 87, 194-203 (2015)
   PUBMED   26319660
  REMARK    GeneRIF: In this study, we show for the first time the expression
            of FAP in activated fibroblasts after MI and its activation by
            TGFbeta1. Effects of FAP on fibroblast migration and gelatinolytic
            activity indicate a potential role in cardiac wound healing
REFERENCE   3  (residues 1 to 761)
  AUTHORS   Kilvaer TK, Khanehkenari MR, Hellevik T, Al-Saad S, Paulsen EE,
            Bremnes RM, Busund LT, Donnem T and Martinez IZ.
  TITLE     Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic
            Impact and Their Correlations with Tumor Molecular Markers
  JOURNAL   PLoS One 10 (8), e0134965 (2015)
   PUBMED   26252379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 761)
  AUTHORS   Augoff K, Hryniewicz-Jankowska A, Tabola R, Czapla L, Szelachowski
            P, Wierzbicki J, Grabowski K and Sikorski AF.
  TITLE     Upregulated expression and activation of membrane-associated
            proteases in esophageal squamous cell carcinoma
  JOURNAL   Oncol Rep 31 (6), 2820-2826 (2014)
   PUBMED   24789592
REFERENCE   5  (residues 1 to 761)
  AUTHORS   Rowton M, Ramos P, Anderson DM, Rhee JM, Cunliffe HE and Rawls A.
  TITLE     Regulation of mesenchymal-to-epithelial transition by PARAXIS
            during somitogenesis
  JOURNAL   Dev Dyn 242 (11), 1332-1344 (2013)
   PUBMED   24038871
REFERENCE   6  (residues 1 to 761)
  AUTHORS   Ajami K, Abbott CA, Obradovic M, Gysbers V, Kahne T, McCaughan GW
            and Gorrell MD.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   7  (residues 1 to 761)
  AUTHORS   Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ and Rettig
            WJ.
  TITLE     Fibroblast activation protein, a dual specificity serine protease
            expressed in reactive human tumor stromal fibroblasts
  JOURNAL   J Biol Chem 274 (51), 36505-36512 (1999)
   PUBMED   10593948
REFERENCE   8  (residues 1 to 761)
  AUTHORS   Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L,
            Pineiro-Sanchez M, Nakahara H, Yeh Y and Chen WT.
  TITLE     A novel protease-docking function of integrin at invadopodia
  JOURNAL   J Biol Chem 274 (35), 24947-24952 (1999)
   PUBMED   10455171
REFERENCE   9  (residues 1 to 761)
  AUTHORS   Niedermeyer J, Enenkel B, Park JE, Lenter M, Rettig WJ, Damm K and
            Schnapp A.
  TITLE     Mouse fibroblast-activation protein--conserved Fap gene
            organization and biochemical function as a serine protease
  JOURNAL   Eur J Biochem 254 (3), 650-654 (1998)
   PUBMED   9688278
REFERENCE   10 (residues 1 to 761)
  AUTHORS   Pineiro-Sanchez ML, Goldstein LA, Dodt J, Howard L, Yeh Y, Tran H,
            Argraves WS and Chen WT.
  TITLE     Identification of the 170-kDa melanoma membrane-bound gelatinase
            (seprase) as a serine integral membrane protease
  JOURNAL   J Biol Chem 272 (12), 7595-7601 (1997)
   PUBMED   9065413
  REMARK    Erratum:[J Biol Chem. 1998 May 22:273(21):13366]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF493782.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF493782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     Protein         1..761
                     /product="prolyl endopeptidase FAP"
                     /note="seprase"
                     /calculated_mol_wt=87713
     Region          106..473
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          553..757
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..761
                     /gene="Fap"
                     /coded_by="NM_138850.1:8..2293"
                     /db_xref="GeneID:192203"
                     /db_xref="RGD:621253"
ORIGIN      
        1 mktwlktvfg vttlvalalv vicivlrpsr vyspegntgr sltlkdilng tfsyktyfpn
       61 wiseqeylhq seddnivfyn ietresyiil snstmksvna tdyglspdrq fiylesdysk
      121 lwrysytaty yiydlqngef vrgyelprpi qylcwspvgs klayvyqnni ylkqrpgdpp
      181 fqitytgren rifngipdwv yeeemlatky alwwspdgky layvefndsd ipiiaysyyg
      241 dgqyprtini pypkagaknp ivrvfivdti yphhvgpiev pvpemiassd yyftwltwvt
      301 nervclqwlk rvqnvsvlsi cdfredwhaw dcpknqehie esrtgwaggf fvstpafsqd
      361 aasyykifsd kdgykhihyi kdtvenaiqi tsgkweaiyi frvtqdslfy ssnefegypg
      421 rrniyrisig nsppskkcvt chlrkercqy ytasfsykak yyalicygpg lpistlhdgr
      481 tdqeiqvlee nkelenalrn iqlpaveikk ledggmtfwy kmilppqfdr skkyplliqv
      541 yggpcsqsvk svfsvnwity laskegivva lvdgrgtafq gdkflhavyr klgvyevedq
      601 ltavrkfiem gfidegriai wgwsyggyvs slalasgtgl fkcgiavapv ssweyyasiy
      661 terfmglptk ddnlehykns tvmaraeyfr nvdyllihgt addnvhfqns aqiakalvna
      721 qvdfqamwys dqnhgissgr sqnhlythmt hflkqcfsls d
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.