LOCUS NP_620205 761 aa linear ROD 26-FEB-2024
DEFINITION prolyl endopeptidase FAP [Rattus norvegicus].
ACCESSION NP_620205
VERSION NP_620205.1
DBSOURCE REFSEQ: accession NM_138850.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 761)
AUTHORS Kilvaer TK, Rakaee M, Hellevik T, Ostman A, Strell C, Bremnes RM,
Busund LT, Donnem T and Martinez-Zubiaurre I.
TITLE Tissue analyses reveal a potential immune-adjuvant function of
FAP-1 positive fibroblasts in non-small cell lung cancer
JOURNAL PLoS One 13 (2), e0192157 (2018)
PUBMED 29415055
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 761)
AUTHORS Tillmanns J, Hoffmann D, Habbaba Y, Schmitto JD, Sedding D,
Fraccarollo D, Galuppo P and Bauersachs J.
TITLE Fibroblast activation protein alpha expression identifies activated
fibroblasts after myocardial infarction
JOURNAL J Mol Cell Cardiol 87, 194-203 (2015)
PUBMED 26319660
REMARK GeneRIF: In this study, we show for the first time the expression
of FAP in activated fibroblasts after MI and its activation by
TGFbeta1. Effects of FAP on fibroblast migration and gelatinolytic
activity indicate a potential role in cardiac wound healing
REFERENCE 3 (residues 1 to 761)
AUTHORS Kilvaer TK, Khanehkenari MR, Hellevik T, Al-Saad S, Paulsen EE,
Bremnes RM, Busund LT, Donnem T and Martinez IZ.
TITLE Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic
Impact and Their Correlations with Tumor Molecular Markers
JOURNAL PLoS One 10 (8), e0134965 (2015)
PUBMED 26252379
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 761)
AUTHORS Augoff K, Hryniewicz-Jankowska A, Tabola R, Czapla L, Szelachowski
P, Wierzbicki J, Grabowski K and Sikorski AF.
TITLE Upregulated expression and activation of membrane-associated
proteases in esophageal squamous cell carcinoma
JOURNAL Oncol Rep 31 (6), 2820-2826 (2014)
PUBMED 24789592
REFERENCE 5 (residues 1 to 761)
AUTHORS Rowton M, Ramos P, Anderson DM, Rhee JM, Cunliffe HE and Rawls A.
TITLE Regulation of mesenchymal-to-epithelial transition by PARAXIS
during somitogenesis
JOURNAL Dev Dyn 242 (11), 1332-1344 (2013)
PUBMED 24038871
REFERENCE 6 (residues 1 to 761)
AUTHORS Ajami K, Abbott CA, Obradovic M, Gysbers V, Kahne T, McCaughan GW
and Gorrell MD.
TITLE Structural requirements for catalysis, expression, and dimerization
in the CD26/DPIV gene family
JOURNAL Biochemistry 42 (3), 694-701 (2003)
PUBMED 12534281
REFERENCE 7 (residues 1 to 761)
AUTHORS Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ and Rettig
WJ.
TITLE Fibroblast activation protein, a dual specificity serine protease
expressed in reactive human tumor stromal fibroblasts
JOURNAL J Biol Chem 274 (51), 36505-36512 (1999)
PUBMED 10593948
REFERENCE 8 (residues 1 to 761)
AUTHORS Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L,
Pineiro-Sanchez M, Nakahara H, Yeh Y and Chen WT.
TITLE A novel protease-docking function of integrin at invadopodia
JOURNAL J Biol Chem 274 (35), 24947-24952 (1999)
PUBMED 10455171
REFERENCE 9 (residues 1 to 761)
AUTHORS Niedermeyer J, Enenkel B, Park JE, Lenter M, Rettig WJ, Damm K and
Schnapp A.
TITLE Mouse fibroblast-activation protein--conserved Fap gene
organization and biochemical function as a serine protease
JOURNAL Eur J Biochem 254 (3), 650-654 (1998)
PUBMED 9688278
REFERENCE 10 (residues 1 to 761)
AUTHORS Pineiro-Sanchez ML, Goldstein LA, Dodt J, Howard L, Yeh Y, Tran H,
Argraves WS and Chen WT.
TITLE Identification of the 170-kDa melanoma membrane-bound gelatinase
(seprase) as a serine integral membrane protease
JOURNAL J Biol Chem 272 (12), 7595-7601 (1997)
PUBMED 9065413
REMARK Erratum:[J Biol Chem. 1998 May 22:273(21):13366]
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF493782.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF493782.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5756307,
SAMEA5760383 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..761
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="3"
/map="3q21"
Protein 1..761
/product="prolyl endopeptidase FAP"
/note="seprase"
/calculated_mol_wt=87713
Region 106..473
/region_name="DPPIV_N"
/note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
pfam00930"
/db_xref="CDD:395744"
Region 553..757
/region_name="Peptidase_S9"
/note="Prolyl oligopeptidase family; pfam00326"
/db_xref="CDD:459761"
CDS 1..761
/gene="Fap"
/coded_by="NM_138850.1:8..2293"
/db_xref="GeneID:192203"
/db_xref="RGD:621253"
ORIGIN
1 mktwlktvfg vttlvalalv vicivlrpsr vyspegntgr sltlkdilng tfsyktyfpn
61 wiseqeylhq seddnivfyn ietresyiil snstmksvna tdyglspdrq fiylesdysk
121 lwrysytaty yiydlqngef vrgyelprpi qylcwspvgs klayvyqnni ylkqrpgdpp
181 fqitytgren rifngipdwv yeeemlatky alwwspdgky layvefndsd ipiiaysyyg
241 dgqyprtini pypkagaknp ivrvfivdti yphhvgpiev pvpemiassd yyftwltwvt
301 nervclqwlk rvqnvsvlsi cdfredwhaw dcpknqehie esrtgwaggf fvstpafsqd
361 aasyykifsd kdgykhihyi kdtvenaiqi tsgkweaiyi frvtqdslfy ssnefegypg
421 rrniyrisig nsppskkcvt chlrkercqy ytasfsykak yyalicygpg lpistlhdgr
481 tdqeiqvlee nkelenalrn iqlpaveikk ledggmtfwy kmilppqfdr skkyplliqv
541 yggpcsqsvk svfsvnwity laskegivva lvdgrgtafq gdkflhavyr klgvyevedq
601 ltavrkfiem gfidegriai wgwsyggyvs slalasgtgl fkcgiavapv ssweyyasiy
661 terfmglptk ddnlehykns tvmaraeyfr nvdyllihgt addnvhfqns aqiakalvna
721 qvdfqamwys dqnhgissgr sqnhlythmt hflkqcfsls d
//