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cytochrome P450 2B15 [Rattus norvegicus]

NCBI Reference Sequence: NP_001129140.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001129140             495 aa            linear   ROD 03-APR-2024
DEFINITION  cytochrome P450 2B15 [Rattus norvegicus].
ACCESSION   NP_001129140 XP_001062874 XP_001070774 XP_001070818 XP_001070869
VERSION     NP_001129140.1
DBSOURCE    REFSEQ: accession NM_001135668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Roberts,E.S., Hopkins,N.E., Zaluzec,E.J., Gage,D.A., Alworth,W.L.
            and Hollenberg,P.F.
  TITLE     Identification of active-site peptides from 3H-labeled
            2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid
            sequencing and mass spectrometry
  JOURNAL   Biochemistry 33 (12), 3766-3771 (1994)
   PUBMED   8142377
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Nakayama,K., Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Cloning and sequencing of a novel rat cytochrome P450 2B-encoding
            gene
  JOURNAL   Gene 136 (1-2), 333-336 (1993)
   PUBMED   8294026
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Friedberg,T., Grassow,M.A., Bartlomowicz-Oesch,B., Siegert,P.,
            Arand,M., Adesnik,M. and Oesch,F.
  TITLE     Sequence of a novel cytochrome CYP2B cDNA coding for a protein
            which is expressed in a sebaceous gland, but not in the liver
  JOURNAL   Biochem J 287 (Pt 3) (Pt 3), 775-783 (1992)
   PUBMED   1445240
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Lacroix,D., Desrochers,M., Lambert,M. and Anderson,A.
  TITLE     Alternative splicing of mRNA encoding rat liver cytochrome P450e
            (P450IIB2)
  JOURNAL   Gene 86 (2), 201-207 (1990)
   PUBMED   2323573
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Pyerin,W. and Taniguchi,H.
  TITLE     Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450
  JOURNAL   EMBO J 8 (10), 3003-3010 (1989)
   PUBMED   2583091
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Oesch,F., Waxman,D.J., Morrissey,J.J., Honscha,W., Kissel,W. and
            Friedberg,T.
  TITLE     Antibodies targeted against hypervariable and constant regions of
            cytochromes P450IIB1 and P450IIB2
  JOURNAL   Arch Biochem Biophys 270 (1), 23-32 (1989)
   PUBMED   2539047
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Affolter,M. and Anderson,A.
  TITLE     Segmental homologies in the coding and 3' non-coding sequences of
            rat liver cytochrome P-450e and P-450b cDNAs and cytochrome
            P-450e-like genes
  JOURNAL   Biochem Biophys Res Commun 118 (2), 655-662 (1984)
   PUBMED   6322758
REFERENCE   9  (residues 1 to 495)
  AUTHORS   Fujii-Kuriyama,Y., Mizukami,Y., Kawajiri,K., Sogawa,K. and
            Muramatsu,M.
  TITLE     Primary structure of a cytochrome P-450: coding nucleotide sequence
            of phenobarbital-inducible cytochrome P-450 cDNA from rat liver
  JOURNAL   Proc Natl Acad Sci U S A 79 (9), 2793-2797 (1982)
   PUBMED   6953431
REFERENCE   10 (residues 1 to 495)
  AUTHORS   Botelho,L.H., Ryan,D.E. and Levin,W.
  TITLE     Amino acid compositions and partial amino acid sequences of three
            highly purified forms of liver microsomal cytochrome P-450 from
            rats treated with polychlorinated biphenyls, phenobarbital, or
            3-methylcholanthrene
  JOURNAL   J Biol Chem 254 (13), 5635-5640 (1979)
   PUBMED   109438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D17349.2.
            
            On or before Oct 5, 2008 this sequence version replaced
            XP_001070818.1, XP_001070869.1, XP_001070774.1, XP_001062874.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..495
                     /product="cytochrome P450 2B15"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P-450b type b; CYPIIB15"
                     /calculated_mol_wt=56189
     Region          63..487
                     /region_name="CYP2B"
                     /note="cytochrome P450 family 2, subfamily B; cd20672"
                     /db_xref="CDD:410765"
     Site            order(74,99,102,105,115..116,207,210,295,298..299,
                     302..303,363..364,366..369,390,437,477..479)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410765"
     Site            order(99,114..115,122,126,180,299..300,303..304,307,358,
                     364,368,370,393,429..431,435,437..439,442..443)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410765"
     Site            129
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000250|UniProtKB:P00176; propagated from
                     UniProtKB/Swiss-Prot (Q64583.2)"
     CDS             1..495
                     /gene="Cyp2b15"
                     /coded_by="NM_001135668.1:1..1488"
                     /db_xref="GeneID:685222"
                     /db_xref="RGD:1596474"
ORIGIN      
        1 melgvllllt ftvgflllla sqnrpkthgh lppgprplpf lgnllqmnrr gllrsfmqlq
       61 ekygdvftvh lgprpvvilc gtdtirealv dqaeafsgrg tvavlhpvvq gygvifange
      121 rwkilrrfsl vtmrnfgmgk rsveerikee aqclveelkk ykgallnpts ifqsiaanii
      181 csivfgerfd ykdhqflrll dliyqtfslm gslssqvfel fsgflkyfpg vhkqisknlq
      241 eilnyidhsv ekhratldpn tprdfintyl lrmekeksnh htefhhqnlv isvlslfftg
      301 tettsttlry sflimlkyph vaekvqkeid qvigshrlpt lddrtkmpyt daviheiqrf
      361 adlipiglph rvtndtmflg yllpkntevy pilssalhdp ryfdhpdtfn pehfldvngt
      421 lkkseaflpf stgkriclge giaqnelfif ftailqnfsl aspvapedid lspinsgisk
      481 ipspyqihfl srcvg
//
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the Cyp2b15 gene (NM_001135668.1).

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