LOCUS NP_001129140 495 aa linear ROD 03-APR-2024
DEFINITION cytochrome P450 2B15 [Rattus norvegicus].
ACCESSION NP_001129140 XP_001062874 XP_001070774 XP_001070818 XP_001070869
VERSION NP_001129140.1
DBSOURCE REFSEQ: accession NM_001135668.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 495)
AUTHORS Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
TITLE Gene and alternative splicing annotation with AIR
JOURNAL Genome Res 15 (1), 54-66 (2005)
PUBMED 15632090
REFERENCE 2 (residues 1 to 495)
AUTHORS Roberts,E.S., Hopkins,N.E., Zaluzec,E.J., Gage,D.A., Alworth,W.L.
and Hollenberg,P.F.
TITLE Identification of active-site peptides from 3H-labeled
2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid
sequencing and mass spectrometry
JOURNAL Biochemistry 33 (12), 3766-3771 (1994)
PUBMED 8142377
REFERENCE 3 (residues 1 to 495)
AUTHORS Nakayama,K., Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-Kuriyama,Y.
TITLE Cloning and sequencing of a novel rat cytochrome P450 2B-encoding
gene
JOURNAL Gene 136 (1-2), 333-336 (1993)
PUBMED 8294026
REFERENCE 4 (residues 1 to 495)
AUTHORS Friedberg,T., Grassow,M.A., Bartlomowicz-Oesch,B., Siegert,P.,
Arand,M., Adesnik,M. and Oesch,F.
TITLE Sequence of a novel cytochrome CYP2B cDNA coding for a protein
which is expressed in a sebaceous gland, but not in the liver
JOURNAL Biochem J 287 (Pt 3) (Pt 3), 775-783 (1992)
PUBMED 1445240
REFERENCE 5 (residues 1 to 495)
AUTHORS Lacroix,D., Desrochers,M., Lambert,M. and Anderson,A.
TITLE Alternative splicing of mRNA encoding rat liver cytochrome P450e
(P450IIB2)
JOURNAL Gene 86 (2), 201-207 (1990)
PUBMED 2323573
REFERENCE 6 (residues 1 to 495)
AUTHORS Pyerin,W. and Taniguchi,H.
TITLE Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450
JOURNAL EMBO J 8 (10), 3003-3010 (1989)
PUBMED 2583091
REFERENCE 7 (residues 1 to 495)
AUTHORS Oesch,F., Waxman,D.J., Morrissey,J.J., Honscha,W., Kissel,W. and
Friedberg,T.
TITLE Antibodies targeted against hypervariable and constant regions of
cytochromes P450IIB1 and P450IIB2
JOURNAL Arch Biochem Biophys 270 (1), 23-32 (1989)
PUBMED 2539047
REFERENCE 8 (residues 1 to 495)
AUTHORS Affolter,M. and Anderson,A.
TITLE Segmental homologies in the coding and 3' non-coding sequences of
rat liver cytochrome P-450e and P-450b cDNAs and cytochrome
P-450e-like genes
JOURNAL Biochem Biophys Res Commun 118 (2), 655-662 (1984)
PUBMED 6322758
REFERENCE 9 (residues 1 to 495)
AUTHORS Fujii-Kuriyama,Y., Mizukami,Y., Kawajiri,K., Sogawa,K. and
Muramatsu,M.
TITLE Primary structure of a cytochrome P-450: coding nucleotide sequence
of phenobarbital-inducible cytochrome P-450 cDNA from rat liver
JOURNAL Proc Natl Acad Sci U S A 79 (9), 2793-2797 (1982)
PUBMED 6953431
REFERENCE 10 (residues 1 to 495)
AUTHORS Botelho,L.H., Ryan,D.E. and Levin,W.
TITLE Amino acid compositions and partial amino acid sequences of three
highly purified forms of liver microsomal cytochrome P-450 from
rats treated with polychlorinated biphenyls, phenobarbital, or
3-methylcholanthrene
JOURNAL J Biol Chem 254 (13), 5635-5640 (1979)
PUBMED 109438
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
D17349.2.
On or before Oct 5, 2008 this sequence version replaced
XP_001070818.1, XP_001070869.1, XP_001070774.1, XP_001062874.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..495
/organism="Rattus norvegicus"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="1"
/map="1q21"
Protein 1..495
/product="cytochrome P450 2B15"
/EC_number="1.14.14.1"
/note="cytochrome P-450b type b; CYPIIB15"
/calculated_mol_wt=56189
Region 63..487
/region_name="CYP2B"
/note="cytochrome P450 family 2, subfamily B; cd20672"
/db_xref="CDD:410765"
Site order(74,99,102,105,115..116,207,210,295,298..299,
302..303,363..364,366..369,390,437,477..479)
/site_type="other"
/note="chemical substrate binding pocket [chemical
binding]"
/db_xref="CDD:410765"
Site order(99,114..115,122,126,180,299..300,303..304,307,358,
364,368,370,393,429..431,435,437..439,442..443)
/site_type="other"
/note="heme binding site [chemical binding]"
/db_xref="CDD:410765"
Site 129
/site_type="phosphorylation"
/note="Phosphoserine, by PKA.
/evidence=ECO:0000250|UniProtKB:P00176; propagated from
UniProtKB/Swiss-Prot (Q64583.2)"
CDS 1..495
/gene="Cyp2b15"
/coded_by="NM_001135668.1:1..1488"
/db_xref="GeneID:685222"
/db_xref="RGD:1596474"
ORIGIN
1 melgvllllt ftvgflllla sqnrpkthgh lppgprplpf lgnllqmnrr gllrsfmqlq
61 ekygdvftvh lgprpvvilc gtdtirealv dqaeafsgrg tvavlhpvvq gygvifange
121 rwkilrrfsl vtmrnfgmgk rsveerikee aqclveelkk ykgallnpts ifqsiaanii
181 csivfgerfd ykdhqflrll dliyqtfslm gslssqvfel fsgflkyfpg vhkqisknlq
241 eilnyidhsv ekhratldpn tprdfintyl lrmekeksnh htefhhqnlv isvlslfftg
301 tettsttlry sflimlkyph vaekvqkeid qvigshrlpt lddrtkmpyt daviheiqrf
361 adlipiglph rvtndtmflg yllpkntevy pilssalhdp ryfdhpdtfn pehfldvngt
421 lkkseaflpf stgkriclge giaqnelfif ftailqnfsl aspvapedid lspinsgisk
481 ipspyqihfl srcvg
//