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oncoprotein-induced transcript 3 protein precursor [Rattus norvegicus]

NCBI Reference Sequence: NP_001001507.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001001507             546 aa            linear   ROD 12-DEC-2024
DEFINITION  oncoprotein-induced transcript 3 protein precursor [Rattus
            norvegicus].
ACCESSION   NP_001001507 XP_228352
VERSION     NP_001001507.1
DBSOURCE    REFSEQ: accession NM_001001507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 546)
  AUTHORS   Yan,B., Zhang,Z.Z., Huang,L.Y., Shen,H.L. and Han,Z.G.
  TITLE     OIT3 deficiency impairs uric acid reabsorption in renal tubule
  JOURNAL   FEBS Lett 586 (6), 760-765 (2012)
   PUBMED   22306318
REFERENCE   2  (residues 1 to 546)
  AUTHORS   Shen,H.L., Xu,Z.G., Huang,L.Y., Liu,D., Lin,D.H., Cao,J.B.,
            Zhang,X., Wang,Z.Q., Wang,W.H., Yang,P.Y. and Han,Z.G.
  TITLE     Liver-specific ZP domain-containing protein (LZP) as a new partner
            of Tamm-Horsfall protein harbors on renal tubules
  JOURNAL   Mol Cell Biochem 321 (1-2), 73-83 (2009)
   PUBMED   18830570
  REMARK    GeneRIF: The finding that LZP might act as a new partner of THP
            would provide novel insights into renal functions related to THP
            and LZP, such as the urothelial permeability barrier and the host
            defense against the adhesion of pathogens.
REFERENCE   3  (residues 1 to 546)
  AUTHORS   Xu,Z.G., Du,J.J., Cui,S.J., Wang,Z.Q., Huo,K.K., Li,Y.Y. and
            Han,Z.G.
  TITLE     Identification of LZP gene from Mus musculus and Rattus norvegicus
            coding for a novel liver-specific ZP domain-containing secretory
            protein
  JOURNAL   DNA Seq 15 (2), 81-87 (2004)
   PUBMED   15346761
  REMARK    GeneRIF: Sequence analysis revealed that human, rat and mouse LZP
            proteins are highly conserved.
REFERENCE   4  (residues 1 to 546)
  AUTHORS   Xu,Z.G., Du,J.J., Zhang,X., Cheng,Z.H., Ma,Z.Z., Xiao,H.S., Yu,L.,
            Wang,Z.Q., Li,Y.Y., Huo,K.K. and Han,Z.G.
  TITLE     A novel liver-specific zona pellucida domain containing protein
            that is expressed rarely in hepatocellular carcinoma
  JOURNAL   Hepatology 38 (3), 735-744 (2003)
   PUBMED   12939600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY353853.1.
            
            On Aug 30, 2004 this sequence version replaced XP_228352.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY353853.1, AY356356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     Protein         1..546
                     /product="oncoprotein-induced transcript 3 protein
                     precursor"
                     /note="oncoprotein-induced transcript 3 protein;
                     liver-specific zona pellucida domain-containing protein"
                     /calculated_mol_wt=58461
     sig_peptide     1..16
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6V0K7.1)"
                     /calculated_mol_wt=1736
     mat_peptide     17..546
                     /product="Oncoprotein-induced transcript 3 protein.
                     /id=PRO_0000298933"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6V0K7.1)"
                     /calculated_mol_wt=58461
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6V0K7.1)"
     Site            116
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6V0K7.1)"
     Region          186..221
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          227..262
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          268..514
                     /region_name="Zona_pellucida"
                     /note="Zona pellucida-like domain; pfam00100"
                     /db_xref="CDD:459673"
     Site            299
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6V0K7.1)"
     Region          524..546
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6V0K7.1)"
     CDS             1..546
                     /gene="Oit3"
                     /gene_synonym="Lzp"
                     /coded_by="NM_001001507.1:106..1746"
                     /db_xref="GeneID:294559"
                     /db_xref="RGD:735082"
ORIGIN      
        1 mplslllacl fttvtlqspv vldpcsayis lnepwrntdh qfdesqsqpl cdnhmdgewy
       61 rftgmagdam ptfcipenhc gthapvwlng shplegdgiv qrqacasfkg ncclwnttve
      121 vkacpggyyv yrlakpsvcf hiycghfydi cdedchgscl dttecacspg tslgpdgqtc
      181 fdenecehnn ggcseicvnl knshrcacgv grvlrsdgkt cediegchsn nggcshsclg
      241 sekgyqcecp rglvlsednh tcqvpvlcks saievsvpre lvgglelflt ntscrgvsng
      301 thvniifslk tcgtvvdvvn dkivasnlvt glpkqtpgss gdiiirtskl lipvtcefpr
      361 lytisegyvp nlrnapleir srnhgifpft leifkdhefe epyretlptl klrdslyfgi
      421 eplvhvsgle slvescfatp takvdeilky ylirdgcvsd dsvkqyssrd hlakhfqvpv
      481 fkfvgkdhke vflhcrvlvc gvldersrca qgchrrvrre agededsagl qsqtltggpi
      541 sidwee
//
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the Oit3 gene (NM_001001507.1).

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