LOCUS NP_001001507 546 aa linear ROD 12-DEC-2024
DEFINITION oncoprotein-induced transcript 3 protein precursor [Rattus
norvegicus].
ACCESSION NP_001001507 XP_228352
VERSION NP_001001507.1
DBSOURCE REFSEQ: accession NM_001001507.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 546)
AUTHORS Yan,B., Zhang,Z.Z., Huang,L.Y., Shen,H.L. and Han,Z.G.
TITLE OIT3 deficiency impairs uric acid reabsorption in renal tubule
JOURNAL FEBS Lett 586 (6), 760-765 (2012)
PUBMED 22306318
REFERENCE 2 (residues 1 to 546)
AUTHORS Shen,H.L., Xu,Z.G., Huang,L.Y., Liu,D., Lin,D.H., Cao,J.B.,
Zhang,X., Wang,Z.Q., Wang,W.H., Yang,P.Y. and Han,Z.G.
TITLE Liver-specific ZP domain-containing protein (LZP) as a new partner
of Tamm-Horsfall protein harbors on renal tubules
JOURNAL Mol Cell Biochem 321 (1-2), 73-83 (2009)
PUBMED 18830570
REMARK GeneRIF: The finding that LZP might act as a new partner of THP
would provide novel insights into renal functions related to THP
and LZP, such as the urothelial permeability barrier and the host
defense against the adhesion of pathogens.
REFERENCE 3 (residues 1 to 546)
AUTHORS Xu,Z.G., Du,J.J., Cui,S.J., Wang,Z.Q., Huo,K.K., Li,Y.Y. and
Han,Z.G.
TITLE Identification of LZP gene from Mus musculus and Rattus norvegicus
coding for a novel liver-specific ZP domain-containing secretory
protein
JOURNAL DNA Seq 15 (2), 81-87 (2004)
PUBMED 15346761
REMARK GeneRIF: Sequence analysis revealed that human, rat and mouse LZP
proteins are highly conserved.
REFERENCE 4 (residues 1 to 546)
AUTHORS Xu,Z.G., Du,J.J., Zhang,X., Cheng,Z.H., Ma,Z.Z., Xiao,H.S., Yu,L.,
Wang,Z.Q., Li,Y.Y., Huo,K.K. and Han,Z.G.
TITLE A novel liver-specific zona pellucida domain containing protein
that is expressed rarely in hepatocellular carcinoma
JOURNAL Hepatology 38 (3), 735-744 (2003)
PUBMED 12939600
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AY353853.1.
On Aug 30, 2004 this sequence version replaced XP_228352.2.
##Evidence-Data-START##
Transcript exon combination :: AY353853.1, AY356356.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760494 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..546
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="20"
/map="20q11"
Protein 1..546
/product="oncoprotein-induced transcript 3 protein
precursor"
/note="oncoprotein-induced transcript 3 protein;
liver-specific zona pellucida domain-containing protein"
/calculated_mol_wt=58461
sig_peptide 1..16
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6V0K7.1)"
/calculated_mol_wt=1736
mat_peptide 17..546
/product="Oncoprotein-induced transcript 3 protein.
/id=PRO_0000298933"
/note="propagated from UniProtKB/Swiss-Prot (Q6V0K7.1)"
/calculated_mol_wt=58461
Site 89
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6V0K7.1)"
Site 116
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6V0K7.1)"
Region 186..221
/region_name="FXa_inhibition"
/note="Coagulation Factor Xa inhibitory site; pfam14670"
/db_xref="CDD:464251"
Region 227..262
/region_name="FXa_inhibition"
/note="Coagulation Factor Xa inhibitory site; pfam14670"
/db_xref="CDD:464251"
Region 268..514
/region_name="Zona_pellucida"
/note="Zona pellucida-like domain; pfam00100"
/db_xref="CDD:459673"
Site 299
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6V0K7.1)"
Region 524..546
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6V0K7.1)"
CDS 1..546
/gene="Oit3"
/gene_synonym="Lzp"
/coded_by="NM_001001507.1:106..1746"
/db_xref="GeneID:294559"
/db_xref="RGD:735082"
ORIGIN
1 mplslllacl fttvtlqspv vldpcsayis lnepwrntdh qfdesqsqpl cdnhmdgewy
61 rftgmagdam ptfcipenhc gthapvwlng shplegdgiv qrqacasfkg ncclwnttve
121 vkacpggyyv yrlakpsvcf hiycghfydi cdedchgscl dttecacspg tslgpdgqtc
181 fdenecehnn ggcseicvnl knshrcacgv grvlrsdgkt cediegchsn nggcshsclg
241 sekgyqcecp rglvlsednh tcqvpvlcks saievsvpre lvgglelflt ntscrgvsng
301 thvniifslk tcgtvvdvvn dkivasnlvt glpkqtpgss gdiiirtskl lipvtcefpr
361 lytisegyvp nlrnapleir srnhgifpft leifkdhefe epyretlptl klrdslyfgi
421 eplvhvsgle slvescfatp takvdeilky ylirdgcvsd dsvkqyssrd hlakhfqvpv
481 fkfvgkdhke vflhcrvlvc gvldersrca qgchrrvrre agededsagl qsqtltggpi
541 sidwee
//