LOCUS NP_783856 153 aa linear PRI 22-SEP-2024
DEFINITION protein SSX4 isoform b [Homo sapiens].
ACCESSION NP_783856 XP_001125871
VERSION NP_783856.1
DBSOURCE REFSEQ: accession NM_175729.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 153)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 2 (residues 1 to 153)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 3 (residues 1 to 153)
AUTHORS Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
Clark,A.G. and Yu,H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 153)
AUTHORS Stark,M.S., Tom,L.N., Boyle,G.M., Bonazzi,V.F., Soyer,H.P.,
Herington,A.C., Pollock,P.M. and Hayward,N.K.
TITLE The 'melanoma-enriched' microRNA miR-4731-5p acts as a tumour
suppressor
JOURNAL Oncotarget 7 (31), 49677-49687 (2016)
PUBMED 27331623
REMARK GeneRIF: loss of miR-4731 expression in stage IV patient tumors
supports melanoma growth by, in part, reducing its regulatory
control of SSX expression levels
REFERENCE 5 (residues 1 to 153)
AUTHORS He,L., Ji,J.N., Liu,S.Q., Xue,E., Liang,Q. and Ma,Z.
TITLE Expression of cancer-testis antigen in multiple myeloma
JOURNAL J Huazhong Univ Sci Technolog Med Sci 34 (2), 181-185 (2014)
PUBMED 24710929
REMARK GeneRIF: The mRNA levels of SSX1 and SSX4 are associated with
multiple myeloma clinical stage
REFERENCE 6 (residues 1 to 153)
AUTHORS Brodin,B., Haslam,K., Yang,K., Bartolazzi,A., Xie,Y., Starborg,M.,
Lundeberg,J. and Larsson,O.
TITLE Cloning and characterization of spliced fusion transcript variants
of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible
regulatory role of the fusion gene product in wild type SYT
expression
JOURNAL Gene 268 (1-2), 173-182 (2001)
PUBMED 11368913
REFERENCE 7 (residues 1 to 153)
AUTHORS Chen,C.H., Chen,G.J., Lee,H.S., Huang,G.T., Yang,P.M., Tsai,L.J.,
Chen,D.S. and Sheu,J.C.
TITLE Expressions of cancer-testis antigens in human hepatocellular
carcinomas
JOURNAL Cancer Lett 164 (2), 189-195 (2001)
PUBMED 11179834
REFERENCE 8 (residues 1 to 153)
AUTHORS dos Santos,N.R., de Bruijn,D.R. and van Kessel,A.G.
TITLE Molecular mechanisms underlying human synovial sarcoma development
JOURNAL Genes Chromosomes Cancer 30 (1), 1-14 (2001)
PUBMED 11107170
REMARK Review article
REFERENCE 9 (residues 1 to 153)
AUTHORS Skytting,B., Nilsson,G., Brodin,B., Xie,Y., Lundeberg,J., Uhlen,M.
and Larsson,O.
TITLE A novel fusion gene, SYT-SSX4, in synovial sarcoma
JOURNAL J Natl Cancer Inst 91 (11), 974-975 (1999)
PUBMED 10359553
REFERENCE 10 (residues 1 to 153)
AUTHORS Gure,A.O., Tureci,O., Sahin,U., Tsang,S., Scanlan,M.J., Jager,E.,
Knuth,A., Pfreundschuh,M., Old,L.J. and Chen,Y.T.
TITLE SSX: a multigene family with several members transcribed in normal
testis and human cancer
JOURNAL Int J Cancer 72 (6), 965-971 (1997)
PUBMED 9378559
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL606490.15.
On Sep 20, 2006 this sequence version replaced XP_001125871.1.
Summary: The product of this gene belongs to the family of highly
homologous synovial sarcoma X (SSX) breakpoint proteins. These
proteins may function as transcriptional repressors. They are also
capable of eliciting spontaneously humoral and cellular immune
responses in cancer patients, and are potentially useful targets in
cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have
been involved in the t(X;18) translocation characteristically found
in all synovial sarcomas. This translocation results in the fusion
of the synovial sarcoma translocation gene on chromosome 18 to one
of the SSX genes on chromosome X. Chromosome Xp11 contains a
segmental duplication resulting in two identical copies of synovial
sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail
orientation. This gene, SSX4, represents the more telomeric copy.
Two transcript variants encoding distinct isoforms have been
identified for this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) lacks a segment in the coding
region which leads to a frameshift, compared to variant 1. The
resulting isoform (b) contains a shorter and distinct C-terminus
compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC103864.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968968, SAMEA2148093
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..153
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp11.23"
Protein 1..153
/product="protein SSX4 isoform b"
/note="protein SSX4; cancer/testis antigen 5.4; synovial
sarcoma, X breakpoint 4"
/calculated_mol_wt=17787
Region 23..82
/region_name="KRAB"
/note="krueppel associated box; smart00349"
/db_xref="CDD:214630"
CDS 1..153
/gene="SSX4"
/gene_synonym="CT5.4"
/coded_by="NM_175729.2:47..508"
/note="isoform b is encoded by transcript variant 2"
/db_xref="CCDS:CCDS43934.1"
/db_xref="GeneID:6759"
/db_xref="HGNC:HGNC:11338"
/db_xref="MIM:300326"
ORIGIN
1 mngddafarr prddaqisek lrkafddiak yfskkewekm kssekivyvy mklnyevmtk
61 lgfkvtlppf mrskraadfh gndfgndrnh rnqverpqmt fgslqrifpk dpkggnmpgp
121 tdcvressww fmkrsatlrk mtsnsprgyd tcp
//