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WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X1 [Columba livia]

NCBI Reference Sequence: XP_005503161.1

Identical Proteins FASTA Graphics 

LOCUS       XP_005503161             570 aa            linear   VRT 24-MAY-2017
DEFINITION  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing
            protein 2 isoform X1 [Columba livia].
ACCESSION   XP_005503161
VERSION     XP_005503161.1
DBLINK      BioProject: PRJNA217047
DBSOURCE    REFSEQ: accession XM_005503104.3
KEYWORDS    RefSeq.
SOURCE      Columba livia (rock pigeon)
  ORGANISM  Columba livia
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae;
            Columba.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_004973285.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On May 8, 2024 this sequence was replaced by
            XP_005503161.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Columba livia Annotation Release 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Columba livia"
                     /db_xref="taxon:8932"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="blood"
                     /geo_loc_name="Denmark: Vordingborg"
                     /collection_date="13-Jun-2010"
                     /breed="Danish Tumbler"
                     /note="bred by Anders Christiansen, Hans Ove Christiansen,
                     and certified by Danmarks Racedueforeninger"
     Protein         1..570
                     /product="WAP, Kazal, immunoglobulin, Kunitz and NTR
                     domain-containing protein 2 isoform X1"
                     /calculated_mol_wt=63846
     Region          39..88
                     /region_name="WAP"
                     /note="WAP-type (Whey Acidic Protein) 'four-disulfide
                     core'; pfam00095"
                     /db_xref="CDD:459672"
     Region          135..171
                     /region_name="KAZAL_FS"
                     /note="Kazal type serine protease inhibitors and
                     follistatin-like domains. Kazal inhibitors inhibit serine
                     proteases, such as, trypsin, chyomotrypsin, avian
                     ovomucoids, and elastases. The inhibitory domain has one
                     reactive site peptide bond, which serves the...; cd00104"
                     /db_xref="CDD:238052"
     Region          207..301
                     /region_name="IgI_3_WFIKKN-like"
                     /note="Third immunoglobulin-like domain of the human
                     WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR
                     domain-containing protein), and similar domains; member of
                     the I-set of Ig superfamily (IgSF) domains; cd05765"
                     /db_xref="CDD:409422"
     Region          207..210
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409422"
     Region          215..218
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409422"
     Region          223..230
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409422"
     Region          237..242
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409422"
     Region          243..245
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409422"
     Region          247..252
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409422"
     Region          260..266
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409422"
     Region          280..288
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409422"
     Region          291..301
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409422"
     Region          322..373
                     /region_name="Kunitz_WFIKKN_1-like"
                     /note="first Kunitz domain of WAP, Kazal, immunoglobulin,
                     Kunitz and NTR domain-containing proteins; cd22605"
                     /db_xref="CDD:438648"
     Site            order(329..333,335..337,352,356)
                     /site_type="other"
                     /note="putative serine protease binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438648"
     Region          380..432
                     /region_name="Kunitz_WFIKKN_2-like"
                     /note="second Kunitz domain of WAP, Kazal, immunoglobulin,
                     Kunitz and NTR domain-containing proteins; cd22606"
                     /db_xref="CDD:438649"
     Site            order(387..391,393..395,410,414)
                     /site_type="other"
                     /note="putative serine protease binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438649"
     Region          449..557
                     /region_name="NTR_WFIKKN"
                     /note="NTR domain, WFIKKN subfamily; WFIKKN proteins
                     contain a C-terminal NTR domain and are putative secreted
                     proteins which may be multivalent protease inhibitors that
                     act on serine proteases as well as metalloproteases. Human
                     WFIKKN and a related protein...; cd03575"
                     /db_xref="CDD:239630"
     Site            order(472,526,533,535)
                     /site_type="active"
                     /note="Metzincin-binding interface [active]"
                     /db_xref="CDD:239630"
     CDS             1..570
                     /gene="WFIKKN2"
                     /coded_by="XM_005503104.3:31..1743"
                     /db_xref="GeneID:102088798"
ORIGIN      
        1 mllvlftrwm willgkssvl lllevslqgr alppirysha gicpndmnpn lwvdaqstck
       61 receadlece tfekccpnvc gtkscvaary mdvkgkkgpv gmpkeatcdr fmciqqgsec
      121 diwdgqpvck ckdrcekeps ftcasdglty ynkcymdaea cikgitlnvv tcryhltwpn
      181 tspippetta rpttaysett vidilppalv nnpvhqsvyv getvsflcdv tgrpkpeitw
      241 ekqvdgkekv imkpnhvrgn vvvtniaqlv iyntqlqdag iytctarnsg gllradfpls
      301 vikgeptske asqnkthfpt declkqpdse dcgeeqtrwy ydakknncft fiygncnsnl
      361 nhfetyencm ltcmngpini cnlpalqghc kayeprwayn sltkqcqsfi yggcggnenn
      421 fesreaceem cpfpknthck ackprqklvt sfcksdfvil griteltedq dsghalvtve
      481 eilkdekmgl kflgkeplei tllnmdwscp cpnmttvdgq liimgdvhng mavlqpdsfv
      541 gtssirrvrk lrevihkktc ellkeflglh
//
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