kcnd3 potassium channel, voltage gated Shal related subfamily D, member 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: kcnd3provided by Xenbase
Official Full Name: potassium channel, voltage gated Shal related subfamily D, member 3provided by Xenbase
Primary source: Xenbase:XB-GENE-5867971
See related: Ensembl:ENSXETG00000013577 AllianceGenome:Xenbase:XB-GENE-5867971
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: kv4.3; K(v)4.3
Summary: Predicted to enable voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transmembrane transport and protein homooligomerization. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (59598793..59825646, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	2	NC_030678.1 (72889152..73114018, complement)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein homooligomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A-type voltage-gated potassium channel KCND3; potassium voltage-gated channel subfamily D member 3

Names: potassium voltage-gated channel, Shal-related subfamily, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102941.1 → NP_001096411.1 A-type voltage-gated potassium channel KCND3

See identical proteins and their annotated locations for NP_001096411.1

Status: PROVISIONAL

Source sequence(s)

BC136062

UniProtKB/TrEMBL

A4IIK9, F6ZDS3

Related

ENSXETP00000029746.3, ENSXETT00000029746.5

Conserved Domains (6) summary

smart00225
Location:42 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:217 → 412

Ion_trans; Ion transport protein

pfam02214
Location:42 → 131

BTB_2; BTB/POZ domain

pfam07885
Location:328 → 408

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:442 → 563

DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

59598793..59825646 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031895616.1 → XP_031751476.1 potassium voltage-gated channel subfamily D member 3 isoform X1

UniProtKB/TrEMBL

A0A6I8PVA3

Related

ENSXETP00000063201.2, ENSXETT00000063787.3

Conserved Domains (3) summary

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)

pfam00520
Location:186 → 412

Ion_trans; Ion transport protein

pfam11879
Location:442 → 544

DUF3399; Domain of unknown function (DUF3399)