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    WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Meleagris gallopavo (turkey) ]

    Gene ID: 100550157, updated on 8-Mar-2024

    Summary

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    Gene symbol
    WFIKKN2
    Gene description
    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
    See related
    Ensembl:ENSMGAG00000008648
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Meleagris gallopavo
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Meleagridinae; Meleagris
    Orthologs
    human mouse all
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    Genomic context

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    See WFIKKN2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current Turkey_5.1 (GCF_000146605.3) 20 NC_015030.2 (9896939..9902508, complement)
    Build 1.1 previous assembly Turkey_2.01 (GCF_000146605.1) 20 NC_015030.1 (10138615..10143264, complement)

    Chromosome 20 - NC_015030.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104913821 Neighboring gene transducer of ERBB2, 1 Neighboring gene uncharacterized LOC116217329 Neighboring gene ankyrin repeat domain-containing protein 40-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Meleagris gallopavo Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Turkey_5.1 Primary Assembly

    Genomic

    1. NC_015030.2 Reference Turkey_5.1 Primary Assembly

      Range
      9896939..9902508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003211581.4 → XP_003211629.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

      UniProtKB/TrEMBL
      G1N923
      Related
      ENSMGAP00000008872.2, ENSMGAT00000009680.2
      Conserved Domains (6) summary
      cd05765
      Location:221 → 301
      Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
      smart00131
      Location:321 → 373
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00104
      Location:135 → 171
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd03575
      Location:449 → 557
      NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
      pfam00014
      Location:380 → 431
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:39 → 88
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein
    Heading Accession and Version

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