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    Cfap69 cilia and flagella associated protein 69 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap69provided by RGD
    Official Full Name
    cilia and flagella associated protein 69provided by RGD
    Primary source
    RGD:6496360
    See related
    EnsemblRapid:ENSRNOG00000006114 AllianceGenome:RGD:6496360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including positive regulation of fertilization; positive regulation of flagellated sperm motility; and response to odorant. Predicted to act upstream of or within sperm axoneme assembly. Predicted to be located in cytoplasm. Predicted to be active in non-motile cilium and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 24. Orthologous to human CFAP69 (cilia and flagella associated protein 69). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 151.3), Brain (RPKM 43.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cfap69 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29334624..29405513)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28379604..28452562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25538513..25611470)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene STEAP family member 1 Neighboring gene STEAP2 metalloreductase Neighboring gene uncharacterized LOC134486556 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene family with sequence similarity 237 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse. Dong FN, et al. Am J Hum Genet, 2018 Apr 5. PMID 29606301, Free PMC Article
    2. Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice. Talaga AK, et al. J Neurosci, 2017 Jun 7. PMID 28495971, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72627

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in olfactory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in olfactory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to odorant IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to odorant ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cilia and flagella associated protein 69; cilia- and flagella-associated protein 69

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431973.1 → NP_001418902.1  cilia and flagella associated protein 69 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AJA3

    2. NM_001431974.1 → NP_001418903.1  cilia and flagella associated protein 69 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AJA3

    3. NM_001431975.1 → NP_001418904.1  cilia and flagella associated protein 69 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AJA3

    4. NM_001431976.1 → NP_001418905.1  cilia and flagella associated protein 69 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AJA3

    5. NM_001431977.1 → NP_001418906.1  cilia and flagella associated protein 69 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    6. NM_001431978.1 → NP_001418907.1  cilia and flagella associated protein 69 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    7. NM_001431979.1 → NP_001418908.1  cilia and flagella associated protein 69 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      Q6P6X4

    8. NM_001431980.1 → NP_001418909.1  cilia and flagella associated protein 69 isoform g

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    9. NM_001431981.1 → NP_001418910.1  cilia and flagella associated protein 69 isoform h

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RNA

    1. NR_197254.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    2. NR_197255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    3. NR_197256.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    4. NR_197257.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    5. NR_197258.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    6. NR_197259.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    7. NR_197260.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    8. NR_197261.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    9. NR_197262.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      29334624..29405513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003749688.6 → XP_003749736.1  cilia- and flagella-associated protein 69 isoform X1

      Related
      ENSRNOP00000093632.2, ENSRNOT00000112626.2

    2. XM_063286814.1 → XP_063142884.1  cilia- and flagella-associated protein 69 isoform X2

    3. XM_008762733.4 → XP_008760955.1  cilia- and flagella-associated protein 69 isoform X2

    4. XM_008762734.4 → XP_008760956.1  cilia- and flagella-associated protein 69 isoform X2

      See identical proteins and their annotated locations for XP_008760956.1

      UniProtKB/TrEMBL
      A0A8I6AJA3

    5. XM_006236074.5 → XP_006236136.1  cilia- and flagella-associated protein 69 isoform X3

    6. XM_039108576.2 → XP_038964504.1  cilia- and flagella-associated protein 69 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007644.1: Suppressed sequence

      Description
      NM_001007644.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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