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    Grin1 glutamate ionotropic receptor NMDA type subunit 1 [ Heterocephalus glaber (naked mole-rat) ]

    Gene ID: 101720185, updated on 3-Dec-2024

    Summary

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    Gene symbol
    Grin1
    Gene description
    glutamate ionotropic receptor NMDA type subunit 1
    See related
    Ensembl:ENSHGLG00000009960
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Heterocephalus glaber
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
    Orthologs
    human mouse all
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    Genomic context

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    See Grin1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624760.1 (777208..800525, complement)

    NW_004624760.1Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 2 Neighboring gene leucine rich repeat containing 26 Neighboring gene vasculin-like Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene dipeptidyl peptidase 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004624760 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NMDA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, NMDA 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HetGla_female_1.0 Primary Assembly

    Genomic

    1. NW_004624760.1 Reference HetGla_female_1.0 Primary Assembly

      Range
      777208..800525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004848773.3 → XP_004848830.1  glutamate receptor ionotropic, NMDA 1 isoform X6

      UniProtKB/TrEMBL
      A0AAX6PD25
      Conserved Domains (7) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623 → 677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam15720
      Location:997 → 1080
      DUF4675; Domain of unknown function (DUF4675)

    2. XM_013073785.2 → XP_012929239.1  glutamate receptor ionotropic, NMDA 1 isoform X10

      UniProtKB/TrEMBL
      A0AAX6QZS7
      Conserved Domains (7) summary
      cd06379
      Location:8 → 383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395 → 799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561 → 824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 357
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:602 → 656
      Ion_trans_2; Ion channel
      pfam10562
      Location:835 → 863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      pfam15720
      Location:976 → 1059
      DUF4675; Domain of unknown function (DUF4675)

    3. XM_004848785.3 → XP_004848842.1  glutamate receptor ionotropic, NMDA 1 isoform X11

      UniProtKB/TrEMBL
      A0AAX6PD08, G5BZF7
      Conserved Domains (5) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    4. XM_004848781.2 → XP_004848838.1  glutamate receptor ionotropic, NMDA 1 isoform X4

      UniProtKB/TrEMBL
      A0A0P6J637, G5BZF7
      Related
      ENSHGLP00000013938.1, ENSHGLT00000014081.1
      Conserved Domains (6) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623 → 677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    5. XM_013073786.1 → XP_012929240.1  glutamate receptor ionotropic, NMDA 1 isoform X1

      UniProtKB/TrEMBL
      A0AAX6QWV3, G5BZF7
      Conserved Domains (6) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623 → 677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    6. XM_021261623.1 → XP_021117282.1  glutamate receptor ionotropic, NMDA 1 isoform X7

      UniProtKB/TrEMBL
      A0AAX6T4V4
      Conserved Domains (5) summary
      cd13719
      Location:263 → 667
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam07885
      Location:469 → 524
      Ion_trans_2; Ion channel
      pfam10562
      Location:703 → 731
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
      cl10011
      Location:1 → 251
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl27975
      Location:748 → 903
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    7. XM_004848787.2 → XP_004848844.1  glutamate receptor ionotropic, NMDA 1 isoform X13

      UniProtKB/TrEMBL
      A0AAX6PDH0, G5BZF7
      Related
      ENSHGLP00000013940.1, ENSHGLT00000014083.1
      Conserved Domains (5) summary
      cd06379
      Location:8 → 383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395 → 799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561 → 824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835 → 863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    8. XM_004848784.2 → XP_004848841.1  glutamate receptor ionotropic, NMDA 1 isoform X8

      UniProtKB/TrEMBL
      A0AAX6PCL2, G5BZF7
      Related
      ENSHGLP00000013939.1, ENSHGLT00000014082.1
      Conserved Domains (5) summary
      cd06379
      Location:8 → 383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395 → 799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561 → 824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835 → 863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    9. XM_004848782.3 → XP_004848839.1  glutamate receptor ionotropic, NMDA 1 isoform X5

      UniProtKB/TrEMBL
      A0AAX6PCP7, G5BZF7
      Conserved Domains (6) summary
      cd06379
      Location:8 → 383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395 → 799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561 → 824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 357
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:602 → 656
      Ion_trans_2; Ion channel
      pfam10562
      Location:835 → 863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    10. XM_013073787.2 → XP_012929241.1  glutamate receptor ionotropic, NMDA 1 isoform X3

      UniProtKB/TrEMBL
      A0AAX6R021, G5BZF7
      Related
      ENSHGLP00000013941.1, ENSHGLT00000014084.1
      Conserved Domains (6) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623 → 677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    11. XM_013073789.2 → XP_012929243.1  glutamate receptor ionotropic, NMDA 1 isoform X9

      UniProtKB/TrEMBL
      A0AAX6QZ17, G5BZF7
      Related
      ENSHGLP00000013942.1, ENSHGLT00000014085.1
      Conserved Domains (6) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623 → 677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    12. XM_004848786.3 → XP_004848843.1  glutamate receptor ionotropic, NMDA 1 isoform X12

      UniProtKB/TrEMBL
      A0AAX6PDF8, G5BZF7
      Conserved Domains (5) summary
      cd06379
      Location:8 → 383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:395 → 799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:561 → 824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 357
      ANF_receptor; Receptor family ligand binding region
      pfam10562
      Location:835 → 863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    13. XM_004848778.3 → XP_004848835.1  glutamate receptor ionotropic, NMDA 1 isoform X2

      UniProtKB/TrEMBL
      A0AAX6PD32, G5BZF7
      Conserved Domains (6) summary
      cd06379
      Location:8 → 404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      cd13719
      Location:416 → 820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:582 → 845
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 378
      ANF_receptor; Receptor family ligand binding region
      pfam07885
      Location:623 → 677
      Ion_trans_2; Ion channel
      pfam10562
      Location:856 → 884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    RNA

    1. XR_002396481.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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