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    Nox1 NADPH oxidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114243, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nox1provided by RGD
    Official Full Name
    NADPH oxidase 1provided by RGD
    Primary source
    RGD:620598
    See related
    EnsemblRapid:ENSRNOG00000048706 AllianceGenome:RGD:620598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to mercury ion; cellular response to platelet-derived growth factor stimulus; and positive regulation of cellular component organization. Part of NADPH oxidase complex. Used to study Parkinson's disease; pulmonary hypertension; transient cerebral ischemia; and vascular dementia. Biomarker of middle cerebral artery infarction; pulmonary hypertension; and traumatic brain injury. Orthologous to human NOX1 (NADPH oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.3), Thymus (RPKM 12.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nox1 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101572338..101625571, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97279058..97332291, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (104909328..104932508, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene sushi-repeat-containing protein, X-linked 2 Neighboring gene synaptotagmin-like 4 Neighboring gene cleavage stimulation factor subunit 2 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene XK related, X-linked Neighboring gene ARF like GTPase 13A Neighboring gene tRNA methyltransferase 2 homolog B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD(P)H oxidase H2O2-forming activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables superoxide-generating NAD(P)H oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables superoxide-generating NADPH oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to hyperoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to mercury ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hydrogen peroxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oxygen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within oxygen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inclusion body assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of integrin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of integrin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NADPH oxidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of NADPH oxidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADPH oxidase 1
    Names
    MOX-1
    MOX1
    NADH/NADPH mitogenic oxidase subunit p65-mox
    NOH-1
    NOX-1
    mitogenic oxidase 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053683.2NP_446135.2  NADPH oxidase 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9WV87
      UniProtKB/TrEMBL
      A6IVE4, M0R934
      Related
      ENSRNOP00000065995.1, ENSRNOT00000075325.3
      Conserved Domains (2) summary
      cd06186
      Location:296563
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:74217
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      101572338..101625571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099398.2XP_038955326.1  NADPH oxidase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG93
      Conserved Domains (2) summary
      cd06186
      Location:232499
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:10153
      Ferric_reduct; Ferric reductase like transmembrane component
    2. XM_039099397.2XP_038955325.1  NADPH oxidase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG93
      Conserved Domains (2) summary
      cd06186
      Location:232499
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:10153
      Ferric_reduct; Ferric reductase like transmembrane component