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    Atp5mc2 ATP synthase membrane subunit c locus 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp5mc2provided by RGD
    Official Full Name
    ATP synthase membrane subunit c locus 2provided by RGD
    Primary source
    RGD:620051
    See related
    EnsemblRapid:ENSRNOG00000015320 AllianceGenome:RGD:620051
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5g2
    Summary
    Enables ligand-gated channel activity. Involved in pore complex assembly; response to 3,3',5-triiodo-L-thyronine; and response to ethanol. Part of cation channel complex. Human ortholog(s) of this gene implicated in renal cell carcinoma and urinary bladder cancer. Orthologous to human ATP5MC2 (ATP synthase membrane subunit c locus 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1941.0), Muscle (RPKM 1596.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp5mc2 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135669847..135680839, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133791341..133799713, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144264207..144272578, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene activating transcription factor 7 Neighboring gene uncharacterized LOC120093744 Neighboring gene calcium binding and coiled coil domain 1 Neighboring gene chondrogenesis-associated transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: Preliminary findings. Campo G, et al. Int J Cardiol, 2016 Oct 15. PMID 27441480
    2. Tumor suppressor RIZ1 in obesity and the PI3K/AKT/mTOR pathway. Xie X, et al. Obesity (Silver Spring), 2016 Feb. PMID 26709097
    3. Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma. Brüggemann M, et al. Transl Oncol, 2017 Aug. PMID 28672194, Free PMC Article
    4. Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma. Morris MR, et al. Oncogene, 2011 Mar 24. PMID 21132003
    5. Batten disease and the control of the Fo subunit c pore by cGMP and calcium. McGeoch JE, et al. Eur J Paediatr Neurol, 2001. PMID 11588987

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ligand-gated channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pore complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit C2, mitochondrial
    Names
    ATP synthase lipid-binding protein, mitochondrial
    ATP synthase proteolipid P2
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
    ATPase protein 9
    ATPase subunit c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133556.2 → NP_598240.1  ATP synthase F(0) complex subunit C2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_598240.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128726
      UniProtKB/Swiss-Prot
      A2VCW6, Q06646
      UniProtKB/TrEMBL
      A0A8I6AM76, A6KCX5
      Related
      ENSRNOP00000020675.3, ENSRNOT00000020676.8
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135669847..135680839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262948.1 → XP_063119018.1  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A2VCW6, Q06646
      UniProtKB/TrEMBL
      A0A8I6AM76, A6KCX5

    2. XM_039078345.2 → XP_038934273.1  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A2VCW6, Q06646
      UniProtKB/TrEMBL
      A0A8I6AM76, A6KCX5
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06646.1 GenPept UniProtKB/Swiss-Prot:Q06646

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous