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    Fap fibroblast activation protein, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fapprovided by RGD
    Official Full Name
    fibroblast activation protein, alphaprovided by RGD
    Primary source
    RGD:621253
    See related
    EnsemblRapid:ENSRNOG00000005679 AllianceGenome:RGD:621253
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including integrin binding activity; peptidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including melanocyte apoptotic process; melanocyte proliferation; and negative regulation of cell proliferation involved in contact inhibition. Predicted to be located in several cellular components, including basal part of cell; cell surface; and lamellipodium. Predicted to be part of peptidase complex. Predicted to be active in plasma membrane. Orthologous to human FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 83.3), Uterus (RPKM 61.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fap in Genome Data Viewer
    Location:
    3q21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (67547398..67616271, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (47138823..47207671, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (48467781..48536242, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101554 Neighboring gene uncharacterized LOC103691814 Neighboring gene glucagon Neighboring gene interferon induced with helicase C domain 1 Neighboring gene SHOC2 leucine-rich repeat scaffold protein, pseudogene 1 Neighboring gene grancalcin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of fibroblast activation proteins in corneal stromal neovascularization. Wang T, et al. Curr Eye Res, 2009 Feb. PMID 19219682
    2. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. Piñeiro-Sánchez ML, et al. J Biol Chem, 1997 Mar 21. PMID 9065413
    3. Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers. Kilvaer TK, et al. PLoS One, 2015. PMID 26252379, Free PMC Article
    4. FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. Ramirez-Montagut T, et al. Oncogene, 2004 Jul 15. PMID 15133496
    5. Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction. Tillmanns J, et al. J Mol Cell Cardiol, 2015 Oct. PMID 26319660

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell proliferation involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of peptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prolyl endopeptidase FAP
    Names
    seprase
    NP_620205.1
    XP_038960153.1
    XP_038960154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138850.1 → NP_620205.1  prolyl endopeptidase FAP

      See identical proteins and their annotated locations for NP_620205.1

      Status: PROVISIONAL

      Source sequence(s)
      AF493782
      UniProtKB/TrEMBL
      A0A8I6G286, A0A9K3Y732, F1LMH7, Q8R492
      Related
      ENSRNOP00000091534.2, ENSRNOT00000096836.2
      Conserved Domains (2) summary
      pfam00326
      Location:553 → 760
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:106 → 473
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      67547398..67616271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104226.2 → XP_038960154.1  prolyl endopeptidase FAP isoform X2

      UniProtKB/TrEMBL
      A0A8I6G286
      Related
      ENSRNOP00000008148.8, ENSRNOT00000008148.8
      Conserved Domains (2) summary
      pfam00326
      Location:553 → 702
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:106 → 473
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. XM_039104225.2 → XP_038960153.1  prolyl endopeptidase FAP isoform X1

      UniProtKB/TrEMBL
      A0A8I6G286
      Conserved Domains (2) summary
      pfam00326
      Location:553 → 728
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:106 → 473
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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