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    Asgr1 asialoglycoprotein receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asgr1provided by RGD
    Official Full Name
    asialoglycoprotein receptor 1provided by RGD
    Primary source
    RGD:2160
    See related
    EnsemblRapid:ENSRNOG00000018693 AllianceGenome:RGD:2160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ASGR; RHL1; RATRHL1
    Summary
    Enables asialoglycoprotein receptor activity. Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR1 (asialoglycoprotein receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1684.1) See more
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    Genomic context

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    See Asgr1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55274299..55278323)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54775727..54779642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56662188..56666086)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene transfer RNA threonine (anticodon AGU) 28 Neighboring gene SEC61 translocon subunit gamma like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles. Li Y, et al. Contrast Media Mol Imaging, 2021. PMID 34131415, Free PMC Article
    2. Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats. Casey CA, et al. J Appl Physiol (1985), 2004 Jan. PMID 12949020
    3. Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Holland EC, et al. Proc Natl Acad Sci U S A, 1984 Dec. PMID 6095287, Free PMC Article
    4. Characterization of the gene encoding the major rat liver asialoglycoprotein receptor. Leung JO, et al. J Biol Chem, 1985 Oct 15. PMID 2995379
    5. Isolation and expression of cDNA clones for a rat liver asialoglycoprotein receptor. Watts C. Biosci Rep, 1986 Jun. PMID 2945599

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles.
      Title: Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles.
    2. a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content.
      Title: Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats.
    3. Asialoglycoprotein receptor functions to help regulate the concentration of glycoproteins bearing sialic acid alpha 2,6GalNAc in the blood.
      Title: The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6GalNAc.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108731

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asialoglycoprotein receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    asialoglycoprotein receptor 1
    Names
    ASGP-R 1
    ASGPR 1
    Asialoglycoprotein receptor 1 (hepatic lectin)
    HL-1
    RHL-1
    asialoglycoprotein receptor (RHL1)
    hepatic lectin 1, RHL1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429873.1 → NP_001416802.1  asialoglycoprotein receptor 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P02706
      UniProtKB/TrEMBL
      A6HG15, A6HG16

    2. NM_001429874.1 → NP_001416803.1  asialoglycoprotein receptor 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HG15

    3. NM_001429875.1 → NP_001416804.1  asialoglycoprotein receptor 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    4. NM_012503.2 → NP_036635.1  asialoglycoprotein receptor 1 isoform a

      See identical proteins and their annotated locations for NP_036635.1

      Status: VALIDATED

      Source sequence(s)
      BC088154
      UniProtKB/Swiss-Prot
      P02706
      UniProtKB/TrEMBL
      A6HG15, A6HG16
      Conserved Domains (2) summary
      cd03590
      Location:153 → 278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15 → 143
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55274299..55278323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085168.2 → XP_038941096.1  asialoglycoprotein receptor 1 isoform X1

      Conserved Domains (2) summary
      cd03590
      Location:153 → 278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15 → 143
      Lectin_N; Hepatic lectin, N-terminal domain

    2. XM_008767769.4 → XP_008765991.1  asialoglycoprotein receptor 1 isoform X2

      See identical proteins and their annotated locations for XP_008765991.1

      UniProtKB/TrEMBL
      A6HG15
      Conserved Domains (2) summary
      cd03590
      Location:149 → 274
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:18 → 139
      Lectin_N; Hepatic lectin, N-terminal domain

    3. XM_006246579.2 → XP_006246641.1  asialoglycoprotein receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006246641.1

      UniProtKB/Swiss-Prot
      P02706
      UniProtKB/TrEMBL
      A6HG15, A6HG16
      Related
      ENSRNOP00000025254.3, ENSRNOT00000025254.7
      Conserved Domains (2) summary
      cd03590
      Location:153 → 278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:15 → 143
      Lectin_N; Hepatic lectin, N-terminal domain

    4. XM_008767768.3 → XP_008765990.1  asialoglycoprotein receptor 1 isoform X2

      Conserved Domains (2) summary
      cd03590
      Location:149 → 274
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:18 → 139
      Lectin_N; Hepatic lectin, N-terminal domain

    5. XM_039085170.2 → XP_038941098.1  asialoglycoprotein receptor 1 isoform X3

      Conserved Domains (2) summary
      cd03590
      Location:53 → 178
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:1 → 43
      Lectin_N; Hepatic lectin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02706.2 GenPept UniProtKB/Swiss-Prot:P02706

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