Slc9a2 solute carrier family 9 member A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc9a2provided by RGD
Official Full Name: solute carrier family 9 member A2provided by RGD
Primary source: RGD:3719
See related: EnsemblRapid:ENSRNOG00000015567 AllianceGenome:RGD:3719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nhe2
Summary: Enables sodium:proton antiporter activity. Involved in sodium ion transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC9A2 (solute carrier family 9 member A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 39.0), Muscle (RPKM 38.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50427612..50510043)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (42932001..43014447)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47386581..47491813)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results provide evidence that NHE2 and AQP2 work in coordination as part of the cellular device that regulates collecting duct cell cycle progression.
Title: AQP2-Induced Acceleration of Renal Cell Proliferation Involves the Activation of a Regulatory Volume Increase Mechanism Dependent on NHE2.
These findings demonstrate suppression of NHE-2 expression on the brush borders in the colonic epithelial cells which is regulated transcriptionally.
Title: Mechanism of down regulation of Na-H exchanger-2 in experimental colitis.
The results demonstrate that in RGM1 cells, migratory velocity is increased by NHE1 activation, while NHE2 activity inhibit this process.
Title: Na(+) /H(+) exchanger NHE1 and NHE2 have opposite effects on migration velocity in rat gastric surface cells.
Enhanced expression of NHE-1, 2 and 4 proteins and mRNAs expression in cervix under genistein influence could help to restore the cervicovaginal fluid pH that might help to prevent cervicovaginal complications related to menopause
Title: Enhanced Expression of Sodium Hydrogen Exchanger (NHE)-1, 2 and 4 in the Cervix of Ovariectomised Rats by Phytoestrogen Genistein.
observations suggest that the butyrate activation of NHE2 would be a potential target to control UC-associated diarrhea
Title: Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis.
Differential expressions of uterine NHE isoforms 1, 2, and 4 could explain the observed changes in the uterine fluid pH under sex steroid effect and at different phases of the oestrous cycle
Title: Differential expression of Na+/H+-exchanger (NHE-1, 2, and 4) proteins and mRNA in rodent's uterus under sex steroid effect and at different phases of the oestrous cycle.
Results support the hypothesis that a blood-brain barrier Na/H exchanger, possibly NHE1 and/or NHE2, is stimulated during ischemia to participate in cerebral edema formation.
Title: Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin.
We conclude that the mechanism of basal control of rat NHE2 gene promoter activity is different in the renal and intestinal epithelium, with Sp3 being the major transcriptional activator of NHE2 gene transcription in the intestinal epithelial cells.
Title: Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells.
renal Na+/H+ exchanger-NHE3 and NHE2 levels are regulated by angiotensin-II
Title: Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2.
increases of two- to threefold in protein and mRNA abundance of NHE2 and NHE3 were observed in ileal regions distal to the anastomosis of proximal small bowel resected rats
Title: Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH94565 (e-PCR)
- UniSTS:119813

Slc9a2 (e-PCR), detects polymorphism
- UniSTS:144435

d9rat125 (e-PCR)
- UniSTS:122499

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 2

Names: H7; NHE-2; Na(+)/H(+) exchanger 2; Na/H ion exchanger; Solute carrier family 9 (sodium/hydrogen exchanger 2), antiporter 2, Na+/H+ (Na+/H+ exchanger 2); solute carrier family 9 (sodium/hydrogen exchanger), member 2; solute carrier family 9 member 2; solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113335.1 → NP_001106806.1 sodium/hydrogen exchanger 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001106806.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BE117286, L11004, L11236

UniProtKB/Swiss-Prot

P48763, Q16434

UniProtKB/TrEMBL

A0A8I6A8M9, A6INP3

Related

ENSRNOP00000021270.4, ENSRNOT00000021270.8

Conserved Domains (3) summary

TIGR00840
Location:75 → 631

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:85 → 485

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:579 → 685

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
NM_012653.2 → NP_036785.2 sodium/hydrogen exchanger 2 isoform 2

See identical proteins and their annotated locations for NP_036785.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks the 5' exon and has an alternate 5' segment, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

BE117286, L11004, L11236

UniProtKB/TrEMBL

A0A8I6A8M9, A6INP4

Related

ENSRNOP00000088725.1, ENSRNOT00000096863.2

Conserved Domains (1) summary

TIGR00840
Location:1 → 515

b_cpa1; sodium/hydrogen exchanger 3