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    Gstt1 glutathione S-transferase theta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gstt1provided by RGD
    Official Full Name
    glutathione S-transferase theta 1provided by RGD
    Primary source
    RGD:2765
    See related
    EnsemblRapid:ENSRNOG00000049771 AllianceGenome:RGD:2765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSTYRS
    Summary
    Enables alkylhalidase activity; glutathione peroxidase activity; and glutathione transferase activity. Involved in several processes, including dichloromethane metabolic process; response to selenium ion; and response to vitamin E. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Biomarker of obesity and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human GSTT1 (glutathione S-transferase theta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 168.6), Kidney (RPKM 153.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gstt1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12856068..12873020)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12856613..12873586)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13799102..13816527)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S28, pseudogene 4 Neighboring gene glutathione S-transferase, theta 4 Neighboring gene uncharacterized LOC134483890 Neighboring gene glutathione S-transferase, theta 3 Neighboring gene D-dopachrome tautomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glutathione transferase theta 1-1-dependent metabolism of the water disinfection byproduct bromodichloromethane. Ross MK, et al. Chem Res Toxicol, 2003 Feb. PMID 12588193
    2. Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis. Lu Y, et al. Gene, 2013 Sep 15. PMID 23827458
    3. Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population. Buentello-Volante B, et al. Exp Eye Res, 2013 Feb. PMID 23206929
    4. Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. Bogdani M, et al. J Endocrinol, 2013 Feb. PMID 23111281, Free PMC Article
    5. A meta-analysis of the relationship between glutathione S-transferases gene polymorphism and hepatocellular carcinoma in Asian population. Chen J, et al. Mol Biol Rep, 2012 Dec. PMID 23053942

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inability of GSTT1 to activate iodinated halomethanes to mutagens in Salmonella.
      Title: Inability of GSTT1 to activate iodinated halomethanes to mutagens in Salmonella.
    2. Functional divergence between human and rat Theta class GST demonstrates that a single point mutation can enable or suppress enzyme activities with different substrates.
      Title: Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alkylhalidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dichloromethane metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase theta-1
    Names
    GST 5-5
    GST class-theta-1
    Glutathione S-transferase 1 (theta)
    glutathione S-transferase 5
    NP_445745.1
    XP_008771081.2
    XP_008771082.1
    XP_008771083.1
    XP_038954369.1
    XP_038954370.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053293.2 → NP_445745.1  glutathione S-transferase theta-1

      See identical proteins and their annotated locations for NP_445745.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086426
      UniProtKB/Swiss-Prot
      Q01579
      UniProtKB/TrEMBL
      A0A8I6ADD6, B6DYQ8
      Related
      ENSRNOP00000001669.4, ENSRNOT00000001669.6
      Conserved Domains (2) summary
      cd03183
      Location:91 → 217
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12856068..12873020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098442.2 → XP_038954370.1  glutathione S-transferase theta-1 isoform X4

      Conserved Domains (2) summary
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
      cl02776
      Location:91 → 117
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_039098441.2 → XP_038954369.1  glutathione S-transferase theta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADD6
      Related
      ENSRNOP00000102694.1, ENSRNOT00000167270.1
      Conserved Domains (2) summary
      PRK11752
      Location:13 → 59
      PRK11752; putative S-transferase; Provisional
      cd03183
      Location:48 → 174
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

    3. XM_008772859.4 → XP_008771081.2  glutathione S-transferase theta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADD6

    4. XM_008772860.4 → XP_008771082.1  glutathione S-transferase theta-1 isoform X3

      See identical proteins and their annotated locations for XP_008771082.1

      UniProtKB/TrEMBL
      A0A8I6ADD6, A6JKH2
      Related
      ENSRNOP00000111258.1, ENSRNOT00000127679.1
      Conserved Domains (3) summary
      cd03183
      Location:41 → 167
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      COG0625
      Location:1 → 151
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:1 → 28
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    5. XM_008772861.3 → XP_008771083.1  glutathione S-transferase theta-1 isoform X5

      Conserved Domains (1) summary
      cl02776
      Location:1 → 99
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01579.2 GenPept UniProtKB/Swiss-Prot:Q01579

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