Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppm1dprovided by RGD
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1Dprovided by RGD
Primary source: RGD:1305460
See related: EnsemblRapid:ENSRNOG00000003329 AllianceGenome:RGD:1305460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wip1
Summary: Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Involved in cellular response to starvation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 154.0), Thymus (RPKM 69.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (70670026..70706030)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (70172603..70208607)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (72909550..72945884)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wip1 Aggravates the Cerulein-Induced Cell Autophagy and Inflammatory Injury by Targeting STING/TBK1/IRF3 in Acute Pancreatitis.
Title: Wip1 Aggravates the Cerulein-Induced Cell Autophagy and Inflammatory Injury by Targeting STING/TBK1/IRF3 in Acute Pancreatitis.
Double immunofluorescence showed colocalization of Wip1 with NF-kappaB in LPS-stimulated primary astrocytes, which indicating a potential interaction between Wip1 with NF-kappaB signaling.
Title: Interaction of Wip1 and NF-κB regulates neuroinflammatory response in astrocytes.
Wip1 might participate in astrocyte activation in optic nerve (ON) injury-induced retinal neuroinflammation via regulating NF-kappaB signaling, which may be closely associated with ON injury
Title: Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-κB signaling pathway.
Suggest that downregulated Wip1 expression plays an important role in Mn-induced neuronal death in the brain striatum via the modulation of p53 signaling.
Title: Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.

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General gene information

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Markers

RH136813 (e-PCR)
- UniSTS:218902

D10Chm138 (e-PCR)
- UniSTS:518059

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in DNA methylation-dependent constitutive heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1D

Names: p53-induced protein phosphatase 1

NP_001099295.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.