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    Dhrs1 dehydrogenase/reductase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrs1provided by RGD
    Official Full Name
    dehydrogenase/reductase 1provided by RGD
    Primary source
    RGD:1359172
    See related
    EnsemblRapid:ENSRNOG00000020264 AllianceGenome:RGD:1359172
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be located in endoplasmic reticulum. Orthologous to human DHRS1 (dehydrogenase/reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 89.0), Kidney (RPKM 79.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhrs1 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33206449..33213776, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29236522..29243807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34424017..34431302, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DFFA-like effector b Neighboring gene leukotriene B4 receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain. Wu Q, et al. Mol Biol Rep, 2001. PMID 12153138
    2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94370

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 1
    Names
    dehydrogenase/reductase (SDR family) member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007621.1 → NP_001007622.1  dehydrogenase/reductase SDR family member 1

      See identical proteins and their annotated locations for NP_001007622.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079263
      UniProtKB/TrEMBL
      A0A8I5ZRF1, A0A8I5ZVF5, F7F1T8, Q6AXY8
      Related
      ENSRNOP00000027511.3, ENSRNOT00000027511.7
      Conserved Domains (2) summary
      cd09763
      Location:5 → 271
      DHRS1-like_SDR_c; human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs
      PRK08303
      Location:1 → 271
      PRK08303; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33206449..33213776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274127.1 → XP_063130197.1  dehydrogenase/reductase SDR family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF1, A0A8I5ZVF5

    2. XM_063274128.1 → XP_063130198.1  dehydrogenase/reductase SDR family member 1 isoform X2

    3. XM_063274130.1 → XP_063130200.1  dehydrogenase/reductase SDR family member 1 isoform X5

    4. XM_063274129.1 → XP_063130199.1  dehydrogenase/reductase SDR family member 1 isoform X4

    5. XM_039093133.2 → XP_038949061.1  dehydrogenase/reductase SDR family member 1 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:5 → 200
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. XM_039093132.2 → XP_038949060.1  dehydrogenase/reductase SDR family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF1, A0A8I5ZVF5
      Conserved Domains (1) summary
      cl21454
      Location:5 → 222
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_039093134.2 → XP_038949062.1  dehydrogenase/reductase SDR family member 1 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:5 → 170
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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