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    Ogdhl oxoglutarate dehydrogenase L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ogdhlprovided by RGD
    Official Full Name
    oxoglutarate dehydrogenase Lprovided by RGD
    Primary source
    RGD:1310916
    See related
    EnsemblRapid:ENSRNOG00000019955 AllianceGenome:RGD:1310916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome. Orthologous to human OGDHL (oxoglutarate dehydrogenase L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 65.9), Adrenal (RPKM 43.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ogdhl in Genome Data Viewer
    Location:
    16p16
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7584666..7610705)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7578343..7604385)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8497495..8523552)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene uncharacterized LOC134482454 Neighboring gene uncharacterized LOC102550503 Neighboring gene similar to human chromosome 10 open reading frame 53 Neighboring gene choline O-acetyltransferase Neighboring gene solute carrier family 18 member A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumption. Solien J, et al. Comp Biochem Physiol A Mol Integr Physiol, 2005 Oct. PMID 15972265
    2. Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart. Bunik V, et al. FEBS J, 2008 Oct. PMID 18783430
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In contrast to the heart complex, where only the known OGDH was determined, the band corresponding to the brain OGDH component was found to also include the novel 2-oxoglutarate dehydrogenase-like (OGDHL) protein.
      Title: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart.
    2. oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase require calcium under hypoxic conditions
      Title: Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumption.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-oxoglutarate dehydrogenase-like, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E1-like
    OGDC-E1-like
    alpha-ketoglutarate dehydrogenase-like
    oxoglutarate dehydrogenase-like
    NP_001382038.1
    XP_038950198.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395109.1 → NP_001382038.1  2-oxoglutarate dehydrogenase-like, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      D3ZQD3
      UniProtKB/TrEMBL
      A0A8L2QEC5, A6KFW1
      Related
      ENSRNOP00000027054.7, ENSRNOT00000027054.7
      Conserved Domains (1) summary
      PRK09404
      Location:46 → 1001
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      7584666..7610705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094270.2 → XP_038950198.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3ZQD3
      UniProtKB/TrEMBL
      A0A8L2QEC5, A6KFW1
      Conserved Domains (1) summary
      PRK09404
      Location:46 → 1001
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106062.2: Suppressed sequence

      Description
      NM_001106062.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZQD3.2 GenPept UniProtKB/Swiss-Prot:D3ZQD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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