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Notch2 notch receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29492, updated on 9-Dec-2024

Summary

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Official Symbol: Notch2provided by RGD
Official Full Name: notch receptor 2provided by RGD
Primary source: RGD:3188
See related: EnsemblRapid:ENSRNOG00000018835 AllianceGenome:RGD:3188
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; NF-kappaB binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in brain development; tissue regeneration; and wound healing. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 260.8), Lung (RPKM 187.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Notch2 in Genome Data Viewer

Location:: 2q34

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (188299336..188432823)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (185610594..185744088)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (200187184..200320403)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCL2- and Notch2-mediated Central Sensitization in a Rat Chronic Pelvic Pain Model.
Title: CCL2- and Notch2-mediated Central Sensitization in a Rat Chronic Pelvic Pain Model.
Bone marrow mesenchymal stem cell-derived exosomes shuttling miR-150-5p alleviates mechanical allodynia in rats by targeting NOTCH2 in microglia.
Title: Bone marrow mesenchymal stem cell-derived exosomes shuttling miR-150-5p alleviates mechanical allodynia in rats by targeting NOTCH2 in microglia.
Overexpression of miR-149-5p Attenuates Cerebral Ischemia/Reperfusion (I/R) Injury by Targeting Notch2.
Title: Overexpression of miR-149-5p Attenuates Cerebral Ischemia/Reperfusion (I/R) Injury by Targeting Notch2.
Perinatal exposure to nonylphenol promotes proliferation of granule cell precursors in offspring cerebellum: Involvement of the activation of Notch2 signaling.
Title: Perinatal exposure to nonylphenol promotes proliferation of granule cell precursors in offspring cerebellum: Involvement of the activation of Notch2 signaling.
Hyperglycemia might inhibit osteoblastogenesis of mesenchymal progenitors via activation of the Notch2 signaling pathway.
Title: Hyperglycemia inhibits osteoblastogenesis of rat bone marrow stromal cells via activation of the Notch2 signaling pathway.
The pattern of Notch2, Numb, and Casp8 gene expression in prefrontal cortex, hippocampus, and cerebellum of the rat brain during formation of spatial memory has been reported.
Title: Pattern of Notch2, Numb, and Cas8 Gene Expression in Relevant Structures of the Rat Brain during Formation of Spatial Memory.
an association between VEGF and Notch2 during the transition from preantral to antral follicles in the ovary of an infantile rat, is reported.
Title: The presence of VEGF and Notch2 during preantral-antral follicular transition in infantile rats: Anatomical evidence and its implications.
The present results suggest that E-cadherin-mediated cell attachment is necessary for the activation of Notch signaling in the anterior pituitary gland but not for the expression of the Notch2 molecule.
Title: Notch signaling-mediated cell-to-cell interaction is dependent on E-cadherin adhesion in adult rat anterior pituitary.
An increase in expression of selective NOTCH receptors (NOTCH1 and -2), ligand (JAGGED2), and target genes (HES1, HEY1, and HEY2) was observed in NP cells following cytokine treatment.
Title: Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.
In situ hybridization detected transcripts of Notch1 and 2 and Jagged1 and 2.
Title: Localization of Notch signaling molecules and their effect on cellular proliferation in adult rat pituitary.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

Notch2 (e-PCR), detects polymorphism
- UniSTS:265730

Notch2 (e-PCR), detects polymorphism
- UniSTS:480308

RH138723 (e-PCR)
- UniSTS:220810

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in atrial septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone remodeling	IEA Inferred from Electronic Annotation more info
involved_in bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholangiocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholangiocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in ciliary body morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ciliary body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
involved_in embryonic limb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in glomerular capillary formation	IEA Inferred from Electronic Annotation more info
involved_in glomerular capillary formation	ISO Inferred from Sequence Orthology more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrahepatic bile duct development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrahepatic bile duct development	ISO Inferred from Sequence Orthology more info
involved_in left/right axis specification	IEA Inferred from Electronic Annotation more info
involved_in left/right axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in marginal zone B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in marginal zone B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in marginal zone B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of an epithelial sheet	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in placenta blood vessel development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within placenta blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	IEA Inferred from Electronic Annotation more info
involved_in podocyte development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proximal tubule development	IEA Inferred from Electronic Annotation more info
involved_in proximal tubule development	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast development	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoclast development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in wound healing	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IEP Inferred from Expression Pattern more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenic locus notch homolog protein 2

Names: notch 2; notch gene homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024358.2 → NP_077334.2 neurogenic locus notch homolog protein 2 precursor

See identical proteins and their annotated locations for NP_077334.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9QW30

UniProtKB/TrEMBL

A6K3C8, G3V8G9

Related

ENSRNOP00000025718.2, ENSRNOT00000025718.6

Conserved Domains (8) summary

cd00054
Location:182 → 218

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1938 → 2062

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1423 → 1456

Notch; LNR domain

pfam06816
Location:1540 → 1591

NOD; NOTCH protein

pfam07684
Location:1619 → 1673

NODP; NOTCH protein

pfam11936
Location:2381 → 2439

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:1948 → 2040

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1943 → 1974

ANK; ANK repeat [structural motif]