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    Lcn5 lipocalin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcn5provided by RGD
    Official Full Name
    lipocalin 5provided by RGD
    Primary source
    RGD:69320
    See related
    AllianceGenome:RGD:69320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Erabp
    Summary
    Predicted to enable small molecule binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 31.4) and Spleen (RPKM 4.3) See more
    Orthologs
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    Genomic context

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    See Lcn5 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28871323..28875335)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8473196..8477208)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2876559..2881305)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ficolin A Neighboring gene lipocalin 8 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene lipocalin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the epididymal retinoic acid binding protein at 2.1 A resolution. Newcomer ME. Structure, 1993 Sep 15. PMID 8069623
    2. Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis. Brooks DE, et al. J Biol Chem, 1986 Apr 15. PMID 2420796
    3. Purification and crystallization of a retinoic acid-binding protein from rat epididymis. Identity with the major androgen-dependent epididymal proteins. Newcomer ME, et al. J Biol Chem, 1990 Aug 5. PMID 2165489
    4. An 18-kDa androgen-regulated protein that modifies galactosyltransferase activity is synthesized by the rat caput epididymidis, but has no structural similarity to rat milk alphalactalbumin. Moore A, et al. Biol Reprod, 1990 Sep. PMID 2125511
    5. Structure and expression of the rat epididymal secretory protein I gene. An androgen-regulated member of the lipocalin superfamily with a rare splice donor site. Girotti M, et al. Biochem J, 1992 Jan 1. PMID 1731756, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epididymal-specific lipocalin-5
    Names
    E-RABP
    ESP-I
    androgen-dependent epididymal 18.5 kDa protein
    epididymal retinoic acid-binding protein
    epididymal secretory protein I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024136.1 → NP_077050.1  epididymal-specific lipocalin-5 precursor

      See identical proteins and their annotated locations for NP_077050.1

      Status: PROVISIONAL

      Source sequence(s)
      X59831
      UniProtKB/Swiss-Prot
      P06911
      UniProtKB/TrEMBL
      A6JT97, A6JT98
      Conserved Domains (2) summary
      pfam00061
      Location:34 → 172
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
      cl21528
      Location:24 → 41
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28871323..28875335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06911.2 GenPept UniProtKB/Swiss-Prot:P06911

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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