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    Fdft1 farnesyl diphosphate farnesyl transferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29580, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fdft1provided by RGD
    Official Full Name
    farnesyl diphosphate farnesyl transferase 1provided by RGD
    Primary source
    RGD:61834
    See related
    EnsemblRapid:ENSRNOG00000021314 AllianceGenome:RGD:61834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables squalene synthase [NAD(P)H] activity. Involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Located in endoplasmic reticulum membrane. Used to study cataract. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 258.9), Kidney (RPKM 209.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fdft1 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41588114..41616168, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37412143..37440198, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46339248..46367302, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene defensin beta 44 Neighboring gene cathepsin B Neighboring gene uncharacterized LOC134482130 Neighboring gene nei-like DNA glycosylase 2 Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC102548615

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93486

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables squalene synthase [NAD(P)H] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables squalene synthase [NAD(P)H] activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in farnesyl diphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in farnesyl diphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in farnesyl diphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    squalene synthase
    Names
    FPP:FPP farnesyltransferase
    SQS
    SS
    farnesyl diphosphate farnesyltransferase
    squalene synthetase
    NP_062111.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019238.2NP_062111.1  squalene synthase

      See identical proteins and their annotated locations for NP_062111.1

      Status: VALIDATED

      Source sequence(s)
      BC081810, BE104849, JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q02769
      UniProtKB/TrEMBL
      A0A8I6GF68, A6K6F7
      Related
      ENSRNOP00000029808.3, ENSRNOT00000032089.6
      Conserved Domains (1) summary
      cl00210
      Location:39370
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      41588114..41616168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)