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    Pou3f2 POU class 3 homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29588, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pou3f2provided by RGD
    Official Full Name
    POU class 3 homeobox 2provided by RGD
    Primary source
    RGD:61946
    See related
    EnsemblRapid:ENSRNOG00000063836 AllianceGenome:RGD:61946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brn-2; OTF-7; oct-7
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pou3f2 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40874631..40880539, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (36077930..36083838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (36677452..36683356, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene PEST proteolytic signal containing nuclear protein, pseudogene 1 Neighboring gene F-box and leucine-rich repeat protein 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102553820 Neighboring gene uncharacterized LOC120102845

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables HMG box domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermis development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within forebrain astrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain ventricular zone progenitor cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within forebrain ventricular zone progenitor cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypothalamus cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hypothalamus cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination in peripheral nervous system IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuroendocrine cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuroendocrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurohypophysis development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neurohypophysis development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    POU domain, class 3, transcription factor 2
    Names
    brain-2
    brain-specific homeobox/POU domain protein 2
    nervous system-specific octamer-binding transcription factor N-Oct-3
    octamer-binding protein 7
    octamer-binding transcription factor 7
    protein Brn-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172085.4NP_742082.2  POU domain, class 3, transcription factor 2

      See identical proteins and their annotated locations for NP_742082.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P56222
      UniProtKB/TrEMBL
      A6IIG2, G3V6U5
      Related
      ENSRNOP00000078344.1, ENSRNOT00000120257.2
      Conserved Domains (2) summary
      smart00352
      Location:264338
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:359412
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      40874631..40880539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)