Pus7 pseudouridine synthase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pus7provided by RGD
Official Full Name: pseudouridine synthase 7provided by RGD
Primary source: RGD:1307054
See related: EnsemblRapid:ENSRNOG00000010572 AllianceGenome:RGD:1307054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307054
Summary: Predicted to enable enzyme binding activity and tRNA pseudouridine(13) synthase activity. Predicted to be involved in several processes, including pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; and regulation of mesoderm development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. Orthologous to human PUS7 (pseudouridine synthase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 60.3), Lung (RPKM 41.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (12252553..12293547)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (11360169..11401139)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (7889727..7931357)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SGC32747 (e-PCR)
- UniSTS:45586

D4Got13 (e-PCR)
- UniSTS:115444

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables pseudouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudouridine synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA pseudouridine(13) synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in tRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pseudouridylate synthase 7 homolog

NP_001164060.1

EC 4.2.1.70

XP_038963152.1

EC 4.2.1.70

XP_038963153.1

EC 4.2.1.70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170589.1 → NP_001164060.1 pseudouridylate synthase 7 homolog

See identical proteins and their annotated locations for NP_001164060.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

D4ADZ9

Related

ENSRNOP00000014063.6, ENSRNOT00000014063.8

Conserved Domains (1) summary

cd02576
Location:124 → 642

PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

12252553..12293547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107224.2 → XP_038963152.1 pseudouridylate synthase 7 homolog isoform X1

UniProtKB/TrEMBL

A0A8I5ZQ13

Related

ENSRNOP00000080175.1, ENSRNOT00000105398.2

Conserved Domains (1) summary

cd02576
Location:124 → 648

PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family
XM_039107225.2 → XP_038963153.1 pseudouridylate synthase 7 homolog isoform X2

UniProtKB/TrEMBL

A6K584

Conserved Domains (1) summary

cd02576
Location:1 → 323

PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family