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    Tnpo3 transportin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296954, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnpo3provided by RGD
    Official Full Name
    transportin 3provided by RGD
    Primary source
    RGD:1308938
    See related
    EnsemblRapid:ENSRNOG00000021758 AllianceGenome:RGD:1308938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 174.3), Thymus (RPKM 171.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tnpo3 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59108278..59197012, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58142954..58220365, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56820023..56897310, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene kielin cysteine rich BMP regulator Neighboring gene interferon regulatory factor 5 Neighboring gene uncharacterized LOC134486568 Neighboring gene uncharacterized LOC102552812 Neighboring gene uncharacterized LOC134486745

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106587.1NP_001100057.1  transportin-3

      See identical proteins and their annotated locations for NP_001100057.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A0A8I6G251, A6IEE3
      Related
      ENSRNOP00000040222.6, ENSRNOT00000043902.7
      Conserved Domains (2) summary
      smart00913
      Location:3396
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121248
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      59108278..59197012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285739.1XP_063141809.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G251
      Related
      ENSRNOP00000074682.3, ENSRNOT00000090038.3
    2. XM_006236186.5XP_006236248.1  transportin-3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G251
      Conserved Domains (1) summary
      pfam08389
      Location:55182
      Xpo1; Exportin 1-like protein
    3. XM_039107279.2XP_038963207.1  transportin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G251
      Related
      ENSRNOP00000110728.1, ENSRNOT00000161952.1
      Conserved Domains (2) summary
      smart00913
      Location:3396
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121248
      Xpo1; Exportin 1-like protein