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    Fkbp3 FKBP prolyl isomerase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fkbp3provided by RGD
    Official Full Name
    FKBP prolyl isomerase 3provided by RGD
    Primary source
    RGD:1304992
    See related
    EnsemblRapid:ENSRNOG00000004629 AllianceGenome:RGD:1304992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be located in nucleus. Orthologous to human FKBP3 (FKBP prolyl isomerase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1793.8), Heart (RPKM 1463.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fkbp3 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (88850137..88862542, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (83113885..83125500, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (86810865..86822115, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene TOG array regulator of axonemal microtubules 1 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127 Neighboring gene FA complementation group M Neighboring gene MIS18 binding protein 1 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression pattern of the Fkbp25 gene during cerebral cortical neurogenesis. Mas C, et al. Gene Expr Patterns, 2005 Jun. PMID 15908283
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP3
    Names
    FK506 binding protein 3, 25kDa
    NP_001100206.2
    XP_063117749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106736.2 → NP_001100206.2  peptidyl-prolyl cis-trans isomerase FKBP3

      See identical proteins and their annotated locations for NP_001100206.2

      Status: VALIDATED

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HBS9, B5DF03, G3V6L9
      Related
      ENSRNOP00000078353.1, ENSRNOT00000103437.2
      Conserved Domains (2) summary
      pfam00254
      Location:124 → 221
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam18410
      Location:6 → 76
      BTHB; Basic tilted helix bundle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      88850137..88862542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261679.1 → XP_063117749.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGJ8, A0A8I6GKQ5
    Nucleotide Protein Strain
    Heading Accession and Version

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