Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nsmce2provided by RGD
Official Full Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligaseprovided by RGD
Primary source: RGD:1305156
See related: EnsemblRapid:ENSRNOG00000003964 AllianceGenome:RGD:1305156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305156
Summary: Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 44.1), Adrenal (RPKM 36.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (92825568..93071037)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (90936112..91173435)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (99677295..99900765)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE119183 (e-PCR)
- UniSTS:249114

D7Rat202 (e-PCR), detects polymorphism
- UniSTS:228150

RH142770 (e-PCR)
- UniSTS:232017

RH128753 (e-PCR)
- UniSTS:212061

BF404967 (e-PCR)
- UniSTS:247169

D7Got73 (e-PCR)
- UniSTS:114366

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO transferase activity	IEA Inferred from Electronic Annotation more info
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic metaphase/anaphase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via recombination	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via recombination	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
part_of Smc5-Smc6 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Smc5-Smc6 complex	IEA Inferred from Electronic Annotation more info
part_of Smc5-Smc6 complex	ISO Inferred from Sequence Orthology more info
part_of Smc5-Smc6 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 SUMO-protein ligase NSE2

Names: E3 SUMO-protein transferase NSE2; MMS21 homolog; non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; non-structural maintenance of chromosomes element 2 homolog

NP_001020047.1

EC 2.3.2.-

XP_006241733.1

EC 2.3.2.-

XP_017450247.1

EC 2.3.2.-

XP_017450249.1

EC 2.3.2.-

XP_038934723.1

EC 2.3.2.-

XP_038934726.1

EC 2.3.2.-

XP_038934727.1

EC 2.3.2.-

XP_063119329.1

EC 2.3.2.-

XP_063119330.1

EC 2.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024876.1 → NP_001020047.1 E3 SUMO-protein ligase NSE2

See identical proteins and their annotated locations for NP_001020047.1

Status: PROVISIONAL

Source sequence(s)

BC097477

UniProtKB/Swiss-Prot

Q4V8A0

UniProtKB/TrEMBL

A0A0G2JW49, A6HRM3

Related

ENSRNOP00000005376.4, ENSRNOT00000005376.7

Conserved Domains (1) summary

cd16651
Location:167 → 236

SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

92825568..93071037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078795.2 → XP_038934723.1 E3 SUMO-protein ligase NSE2 isoform X3

Conserved Domains (1) summary

cd16651
Location:133 → 202

SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins
XM_017594758.3 → XP_017450247.1 E3 SUMO-protein ligase NSE2 isoform X1

UniProtKB/TrEMBL

A0A8I6A069, A6HRM2

Related

ENSRNOP00000085874.1, ENSRNOT00000099968.2

Conserved Domains (1) summary

pfam11789
Location:182 → 242

zf-Nse; Zinc-finger of the MIZ type in Nse subunit
XM_063263259.1 → XP_063119329.1 E3 SUMO-protein ligase NSE2 isoform X2
XM_039078798.2 → XP_038934726.1 E3 SUMO-protein ligase NSE2 isoform X6

UniProtKB/TrEMBL

A6HRM4
XM_017594760.3 → XP_017450249.1 E3 SUMO-protein ligase NSE2 isoform X4
XM_063263260.1 → XP_063119330.1 E3 SUMO-protein ligase NSE2 isoform X5
XM_006241671.4 → XP_006241733.1 E3 SUMO-protein ligase NSE2 isoform X8

UniProtKB/TrEMBL

A0A8I6AS08

Related

ENSRNOP00000097544.1, ENSRNOT00000102133.2
XM_039078799.2 → XP_038934727.1 E3 SUMO-protein ligase NSE2 isoform X7