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    Gpr137c G protein-coupled receptor 137C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr137cprovided by RGD
    Official Full Name
    G protein-coupled receptor 137Cprovided by RGD
    Primary source
    RGD:1563070
    See related
    EnsemblRapid:ENSRNOG00000026328 AllianceGenome:RGD:1563070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563070
    Summary
    Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be active in lysosomal membrane. Orthologous to human GPR137C (G protein-coupled receptor 137C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 63.6), Heart (RPKM 6.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr137c in Genome Data Viewer
    Location:
    15p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (20905923..20972318)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18425939..18492588)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19547783..19615717)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096942 Neighboring gene prostaglandin E receptor 2 Neighboring gene ribosomal protein S10 like 6 Neighboring gene thioredoxin domain containing 16 Neighboring gene REST corepressor 2, pseudogene 1 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene serine/threonine/tyrosine interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein GPR137C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134541.4 → NP_001128013.2  integral membrane protein GPR137C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZFP1
      Related
      ENSRNOP00000031370.7, ENSRNOT00000036235.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      20905923..20972318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093254.2 → XP_038949182.1  integral membrane protein GPR137C isoform X1

      Conserved Domains (2) summary
      cd21464
      Location:44 → 66
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:36 → 357
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_063274202.1 → XP_063130272.1  integral membrane protein GPR137C isoform X2

    3. XM_063274203.1 → XP_063130273.1  integral membrane protein GPR137C isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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