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    Ppp1r3c protein phosphatase 1, regulatory subunit 3C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309513, updated on 9-Dec-2024

    Summary

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    Symbol
    Ppp1r3cprovided by RGD
    Full Name
    protein phosphatase 1, regulatory subunit 3Cprovided by RGD
    Primary source
    RGD:1309132
    See related
    AllianceGenome:RGD:1309132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    R5; PTG
    Summary
    Enables [phosphorylase] phosphatase activity and enzyme binding activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1044.3), Liver (RPKM 443.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r3c in Genome Data Viewer
    Location:
    1q53
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243873524..243878527, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234460958..234465961, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255371830..255376833, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC134485231 Neighboring gene uncharacterized LOC120100025 Neighboring gene uncharacterized LOC102553702 Neighboring gene uncharacterized LOC134485232

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. O'Doherty RM, et al. J Clin Invest, 2000 Feb. PMID 10683377, Free PMC Article
    2. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, et al. Biochem J, 2001 Dec 1. PMID 11716774, Free PMC Article
    3. PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Printen JA, et al. Science, 1997 Mar 7. PMID 9045612
    4. PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease. Turnbull J, et al. PLoS Genet, 2011 Apr. PMID 21552327, Free PMC Article
    5. Abnormal metabolism of glycogen phosphate as a cause for Lafora disease. Tagliabracci VS, et al. J Biol Chem, 2008 Dec 5. PMID 18852261, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables [phosphorylase] phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycogen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of glycogen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glycogen granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 3C
    Names
    PP1 subunit R5
    protein phosphatase 1 regulatory subunit 3C-like
    protein phosphatase 1 regulatory subunit 5
    protein phosphatase 1, regulatory (inhibitor) subunit 3C
    protein targeting to glycogen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012072.1 → NP_001012072.1  protein phosphatase 1 regulatory subunit 3C

      See identical proteins and their annotated locations for NP_001012072.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085894
      UniProtKB/Swiss-Prot
      Q5U2R5
      UniProtKB/TrEMBL
      A6I157, G3V8E0
      Conserved Domains (1) summary
      pfam03370
      Location:151 → 256
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      243873524..243878527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2R5.1 GenPept UniProtKB/Swiss-Prot:Q5U2R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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