Ubash3a ubiquitin associated and SH3 domain containing, A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubash3aprovided by RGD
Official Full Name: ubiquitin associated and SH3 domain containing, Aprovided by RGD
Primary source: RGD:1310305
See related: EnsemblRapid:ENSRNOG00000001167 AllianceGenome:RGD:1310305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in negative regulation of T cell receptor signaling pathway. Predicted to act upstream of or within regulation of cytokine production. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 100.7), Spleen (RPKM 32.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (9292819..9336036)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (9291471..9334685)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9941102..9986012)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.
Title: T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within collagen-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cytokine production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-associated and SH3 domain-containing protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401235.1 → NP_001388164.1 ubiquitin-associated and SH3 domain-containing protein A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6AZI9, D3ZY64

Related

ENSRNOP00000094194.2, ENSRNOT00000119947.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

9292819..9336036

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098727.2 → XP_038954655.1 ubiquitin-associated and SH3 domain-containing protein A isoform X3

Conserved Domains (2) summary

cd11937
Location:241 → 300

SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A

cd14300
Location:25 → 61

UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins
XM_063279154.1 → XP_063135224.1 ubiquitin-associated and SH3 domain-containing protein A isoform X2
XM_039098726.2 → XP_038954654.1 ubiquitin-associated and SH3 domain-containing protein A isoform X1

UniProtKB/TrEMBL

A0A8I6AZI9, D3ZY64

Conserved Domains (3) summary

cd11937
Location:241 → 300

SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A

cd14300
Location:25 → 61

UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins

pfam00300
Location:413 → 575

His_Phos_1; Histidine phosphatase superfamily (branch 1)

RNA

XR_005497253.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107620.1: Suppressed sequence

Description

NM_001107620.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.