Myh7b myosin heavy chain 7B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh7bprovided by RGD
Official Full Name: myosin heavy chain 7Bprovided by RGD
Primary source: RGD:1307994
See related: EnsemblRapid:ENSRNOG00000018997 AllianceGenome:RGD:1307994
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Involved in regulation of CAMKK-AMPK signaling cascade; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Predicted to be located in cardiac myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 126.2), Kidney (RPKM 60.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164537211..164582441)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144076911..144122714)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151105038..151150621)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading.
Title: The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading.
Myosin II motor activity is emerging as a broad regulatory mechanism for control over complex actin networks within dendritic spines.
Title: Regulation of synapse structure and function by distinct myosin II motors.
Myh7b, the ortholog of slow myosin 2 (SM2) of frogs and birds, is detected as mRNA in heart, slow muscles and extraocular muscles. MYH7b protein is detected only in a minor fiber population in extraocular muscles, corresponding to slow-tonic fibers.
Title: Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.

Submit: New GeneRIF Correction

General gene information

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Markers

RH126268 (e-PCR)
- UniSTS:162976

Myh7b (e-PCR), detects polymorphism
- UniSTS:530877

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of CAMKK-AMPK signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cardiac myofibril	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin-7B

Names: myosin, heavy chain 7B, cardiac muscle, beta; myosin, heavy polypeptide 7B, cardiac muscle, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107794.2 → NP_001101264.2 myosin-7B

See identical proteins and their annotated locations for NP_001101264.2

Status: PROVISIONAL

Source sequence(s)

EU241478

UniProtKB/TrEMBL

B6RK61

Related

ENSRNOP00000106404.1, ENSRNOT00000148538.1

Conserved Domains (3) summary

cd14927
Location:98 → 773

MYSc_Myh7b; class II myosin heavy chain 7b, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:32 → 71

Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

164537211..164582441

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105078.2 → XP_038961006.1 myosin-7B isoform X1

UniProtKB/TrEMBL

B6RK61

Conserved Domains (3) summary

cd14927
Location:98 → 773

MYSc_Myh7b; class II myosin heavy chain 7b, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:32 → 71

Myosin_N; Myosin N-terminal SH3-like domain
XM_039105079.2 → XP_038961007.1 myosin-7B isoform X2

Conserved Domains (3) summary

cd14927
Location:98 → 773

MYSc_Myh7b; class II myosin heavy chain 7b, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:32 → 71

Myosin_N; Myosin N-terminal SH3-like domain
XM_017591783.3 → XP_017447272.1 myosin-7B isoform X1

UniProtKB/TrEMBL

B6RK61

Conserved Domains (3) summary

cd14927
Location:98 → 773

MYSc_Myh7b; class II myosin heavy chain 7b, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:32 → 71

Myosin_N; Myosin N-terminal SH3-like domain
XM_039105080.2 → XP_038961008.1 myosin-7B isoform X3

Conserved Domains (2) summary

pfam01576
Location:624 → 1701

Myosin_tail_1; Myosin tail

cl22853
Location:1 → 544

Motor_domain; Myosin and Kinesin motor domain