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    Mdh1b malate dehydrogenase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdh1bprovided by RGD
    Official Full Name
    malate dehydrogenase 1Bprovided by RGD
    Primary source
    RGD:1307874
    See related
    EnsemblRapid:ENSRNOG00000012891 AllianceGenome:RGD:1307874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Orthologous to human MDH1B (malate dehydrogenase 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 147.9), Lung (RPKM 16.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mdh1b in Genome Data Viewer
    Location:
    9q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (72614185..72661820, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (65120370..65168008, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (70403612..70450204, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 237 member A Neighboring gene dystrotelin Neighboring gene dnaJ homolog subfamily A member 1 pseudogene Neighboring gene FAST kinase domains 2 Neighboring gene uncharacterized LOC108351943 Neighboring gene uncharacterized LOC134480376

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative malate dehydrogenase 1B
    Names
    malate dehydrogenase 1B, NAD (soluble)
    XP_017451959.1
    XP_017451960.1
    XP_017451961.1
    XP_038939577.1
    XP_038939578.1
    XP_038939580.1
    XP_038939581.1
    XP_038939582.1
    XP_038939583.1
    XP_038939585.1
    XP_038939586.1
    XP_063123283.1
    XP_063123284.1
    XP_063123285.1
    XP_063123286.1
    XP_063123287.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108221.2 → NP_001101691.2  putative malate dehydrogenase 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JVU8, A0A8I5XW88
      Related
      ENSRNOP00000017207.4, ENSRNOT00000017207.7

    2. NM_001432733.1 → NP_001419662.1  putative malate dehydrogenase 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      72614185..72661820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267217.1 → XP_063123287.1  putative malate dehydrogenase 1B isoform X9

    2. XM_017596471.3 → XP_017451960.1  putative malate dehydrogenase 1B isoform X5

      Related
      ENSRNOP00000069626.2, ENSRNOT00000086391.3

    3. XM_039083653.2 → XP_038939581.1  putative malate dehydrogenase 1B isoform X6

      UniProtKB/TrEMBL
      A0A8I5XW88
      Conserved Domains (1) summary
      cl21454
      Location:35 → 449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_063267216.1 → XP_063123286.1  putative malate dehydrogenase 1B isoform X6

      UniProtKB/TrEMBL
      A0A8I5XW88

    5. XM_039083650.2 → XP_038939578.1  putative malate dehydrogenase 1B isoform X3

      UniProtKB/TrEMBL
      A0A8I5XW88
      Conserved Domains (1) summary
      cl21454
      Location:17 → 467
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. XM_017596472.3 → XP_017451961.1  putative malate dehydrogenase 1B isoform X7

      UniProtKB/TrEMBL
      A0A8I5XW88

    7. XM_017596470.3 → XP_017451959.1  putative malate dehydrogenase 1B isoform X4

      UniProtKB/TrEMBL
      A0A8I5XW88
      Related
      ENSRNOP00000077547.2, ENSRNOT00000097252.2

    8. XM_063267213.1 → XP_063123283.1  putative malate dehydrogenase 1B isoform X2

      UniProtKB/TrEMBL
      A0A8I5XW88

    9. XM_039083654.2 → XP_038939582.1  putative malate dehydrogenase 1B isoform X6

      UniProtKB/TrEMBL
      A0A8I5XW88
      Conserved Domains (1) summary
      cl21454
      Location:35 → 449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    10. XM_063267214.1 → XP_063123284.1  putative malate dehydrogenase 1B isoform X3

      UniProtKB/TrEMBL
      A0A8I5XW88

    11. XM_063267215.1 → XP_063123285.1  putative malate dehydrogenase 1B isoform X6

      UniProtKB/TrEMBL
      A0A8I5XW88

    12. XM_039083649.2 → XP_038939577.1  putative malate dehydrogenase 1B isoform X1

      UniProtKB/TrEMBL
      A0A8I5XW88
      Conserved Domains (1) summary
      cl21454
      Location:44 → 494
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    13. XM_039083657.2 → XP_038939585.1  putative malate dehydrogenase 1B isoform X8

      Conserved Domains (1) summary
      cl21454
      Location:44 → 392
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    14. XM_039083652.2 → XP_038939580.1  putative malate dehydrogenase 1B isoform X6

      UniProtKB/TrEMBL
      A0A8I5XW88
      Conserved Domains (1) summary
      cl21454
      Location:35 → 449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    15. XM_039083655.2 → XP_038939583.1  putative malate dehydrogenase 1B isoform X6

      UniProtKB/TrEMBL
      A0A8I5XW88
      Conserved Domains (1) summary
      cl21454
      Location:35 → 449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    16. XM_039083658.2 → XP_038939586.1  putative malate dehydrogenase 1B isoform X10

      Conserved Domains (1) summary
      cl21454
      Location:44 → 339
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_005488912.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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