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    Gpc4 glypican 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317322, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpc4provided by RGD
    Official Full Name
    glypican 4provided by RGD
    Primary source
    RGD:1359399
    See related
    EnsemblRapid:ENSRNOG00000002413 AllianceGenome:RGD:1359399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of presynapse assembly. Is active in glutamatergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in Keipert syndrome. Orthologous to human GPC4 (glypican 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 397.2), Adrenal (RPKM 244.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Gpc4 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (136565536..136676142, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (131644711..131755349, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (139354325..139464876, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550607 Neighboring gene MAGE family member A14 Neighboring gene high mobility group protein B4-like Neighboring gene ferritin light chain 1 like 1 Neighboring gene ribosomal protein L7, pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014108.1NP_001014130.1  glypican-4 precursor

      See identical proteins and their annotated locations for NP_001014130.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081962
      UniProtKB/TrEMBL
      Q642B0
      Related
      ENSRNOP00000003282.4, ENSRNOT00000003282.7
      Conserved Domains (1) summary
      pfam01153
      Location:24552
      Glypican; Glypican

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      136565536..136676142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257580.5XP_006257642.1  glypican-4 isoform X1

      See identical proteins and their annotated locations for XP_006257642.1

      UniProtKB/TrEMBL
      Q642B0
      Conserved Domains (1) summary
      pfam01153
      Location:24552
      Glypican; Glypican