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    Pcdh7 protocadherin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcdh7provided by RGD
    Official Full Name
    protocadherin 7provided by RGD
    Primary source
    RGD:1303209
    See related
    EnsemblRapid:ENSRNOG00000063828 AllianceGenome:RGD:1303209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human PCDH7 (protocadherin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 266.6), Brain (RPKM 166.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcdh7 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (56684817..57114976, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (52471801..52901696, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (54649054..55081632, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor pseudogene 103 Neighboring gene microfibrillar-associated protein 1A, pseudogene 3 Neighboring gene uncharacterized LOC134481751 Neighboring gene large ribosomal subunit protein uL6-like Neighboring gene uncharacterized LOC134481750 Neighboring gene uncharacterized LOC102549643 Neighboring gene uncharacterized LOC102549744 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function. Wang Y, et al. Sci Rep, 2020 Jul 2. PMID 32616769, Free PMC Article
    2. Fibroblast cell shape and adhesion in vitro is altered by overexpression of the 7a and 7b isoforms of protocadherin 7, but not the 7c isoform. Yoshida K. Cell Mol Biol Lett, 2003. PMID 12949613
    3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protocadherin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004087.2 → NP_001004087.1  protocadherin-7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001004087.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AGF8, Q68HB5
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin; Protocadherin

    2. NM_001401429.1 → NP_001388358.1  protocadherin-7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AGF8, Q68HB6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      56684817..57114976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273350.1 → XP_063129420.1  protocadherin-7 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AGF8

    2. XM_017599293.3 → XP_017454782.1  protocadherin-7 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AHU7

    3. XM_063273348.1 → XP_063129418.1  protocadherin-7 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AHU7

    4. XM_039092182.2 → XP_038948110.1  protocadherin-7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF8
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    5. XM_039092180.2 → XP_038948108.1  protocadherin-7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGF8
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    6. XM_063273347.1 → XP_063129417.1  protocadherin-7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AHU7
      Related
      ENSRNOP00000089275.2, ENSRNOT00000111039.2

    7. XM_063273346.1 → XP_063129416.1  protocadherin-7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGF8

    8. XM_063273345.1 → XP_063129415.1  protocadherin-7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGF8
      Related
      ENSRNOP00000089078.2, ENSRNOT00000107576.2

    9. XM_017599291.3 → XP_017454780.1  protocadherin-7 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A8C1, A0A8I6AGF8, A6IJE6
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin; Protocadherin

    10. XM_063273351.1 → XP_063129421.1  protocadherin-7 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AGF8

    11. XM_063273349.1 → XP_063129419.1  protocadherin-7 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AGF8
      Related
      ENSRNOP00000079925.2, ENSRNOT00000109661.2

    12. XM_063273352.1 → XP_063129422.1  protocadherin-7 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AGF8

    13. XM_006251023.5 → XP_006251085.1  protocadherin-7 isoform X12

      See identical proteins and their annotated locations for XP_006251085.1

      UniProtKB/TrEMBL
      A0A8I6AHU7, A6IJE8, F7FNT4, Q68HB8
      Related
      ENSRNOP00000045705.5, ENSRNOT00000049245.7
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin; Protocadherin
    Nucleotide Protein Strain
    Heading Accession and Version

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