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    Mpped2 metallophosphoesterase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpped2provided by RGD
    Official Full Name
    metallophosphoesterase domain containing 2provided by RGD
    Primary source
    RGD:735060
    See related
    EnsemblRapid:ENSRNOG00000004863 AllianceGenome:RGD:735060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C11orf8; C11orf8h
    Summary
    Enables manganese ion binding activity; phosphoric diester hydrolase activity; and purine ribonucleotide binding activity. Orthologous to human MPPED2 (metallophosphoesterase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 25.5), Adrenal (RPKM 18.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpped2 in Genome Data Viewer
    Location:
    3q33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (113635614..113810307)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (93180895..93355605)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (97720308..97899735)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene doublecortin domain containing 1, pseudogene 1 Neighboring gene doublecortin domain containing 1 Neighboring gene histidine triad nucleotide binding protein 1, pseudogene 4 Neighboring gene ARF like GTPase 14 effector protein Neighboring gene follicle stimulating hormone subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. Dermol U, et al. J Mol Biol, 2011 Sep 23. PMID 21824479
    2. A WAGR region gene between PAX-6 and FSHB expressed in fetal brain. Schwartz F, et al. Hum Genet, 1994 Dec. PMID 7527372
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoric diester hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metallophosphoesterase MPPED2
    Names
    239FB
    fetal brain protein 239 homolog
    metallophosphoesterase domain-containing protein 2
    putative C11orf8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198778.3 → NP_942073.2  metallophosphoesterase MPPED2

      See identical proteins and their annotated locations for NP_942073.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      B1WBP0, Q8CFG1
      Related
      ENSRNOP00000062716.1, ENSRNOT00000065168.4
      Conserved Domains (2) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
      pfam00149
      Location:59 → 255
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      113635614..113810307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234683.5 → XP_006234745.1  metallophosphoesterase MPPED2 isoform X1

      See identical proteins and their annotated locations for XP_006234745.1

      UniProtKB/Swiss-Prot
      B1WBP0, Q8CFG1
      Conserved Domains (2) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
      pfam00149
      Location:59 → 255
      Metallophos; Calcineurin-like phosphoesterase

    2. XM_006234682.5 → XP_006234744.1  metallophosphoesterase MPPED2 isoform X1

      See identical proteins and their annotated locations for XP_006234744.1

      UniProtKB/Swiss-Prot
      B1WBP0, Q8CFG1
      Conserved Domains (2) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
      pfam00149
      Location:59 → 255
      Metallophos; Calcineurin-like phosphoesterase

    3. XM_006234681.5 → XP_006234743.1  metallophosphoesterase MPPED2 isoform X1

      See identical proteins and their annotated locations for XP_006234743.1

      UniProtKB/Swiss-Prot
      B1WBP0, Q8CFG1
      Conserved Domains (2) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
      pfam00149
      Location:59 → 255
      Metallophos; Calcineurin-like phosphoesterase

    4. XM_039105449.2 → XP_038961377.1  metallophosphoesterase MPPED2 isoform X2

      UniProtKB/TrEMBL
      A6HNZ1
      Conserved Domains (1) summary
      cd07379
      Location:72 → 145
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    5. XM_039105448.2 → XP_038961376.1  metallophosphoesterase MPPED2 isoform X2

      UniProtKB/TrEMBL
      A6HNZ1
      Conserved Domains (1) summary
      cd07379
      Location:72 → 145
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1WBP0.1 GenPept UniProtKB/Swiss-Prot:B1WBP0

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