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    Itfg2 integrin alpha FG-GAP repeat containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itfg2provided by RGD
    Official Full Name
    integrin alpha FG-GAP repeat containing 2provided by RGD
    Primary source
    RGD:1311944
    See related
    EnsemblRapid:ENSRNOG00000006264 AllianceGenome:RGD:1311944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311944
    Summary
    Predicted to be involved in cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within germinal center B cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; lysosomal membrane; and nucleoplasm. Predicted to be part of KICSTOR complex. Orthologous to human ITFG2 (integrin alpha FG-GAP repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 49.9), Thymus (RPKM 47.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itfg2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163371125..163384676, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161684249..161698315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (161730643..161744281, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene forkhead box M1 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene uncharacterized LOC120102402 Neighboring gene FKBP prolyl isomerase 4 Neighboring gene uncharacterized LOC102554670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model. Al-Shami A, et al. J Immunol, 2013 Oct 1. PMID 23997217
    2. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Wolfson RL, et al. Nature, 2017 Mar 16. PMID 28199306, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within germinal center B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of KICSTOR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of KICSTOR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KICSTOR complex protein ITFG2
    Names
    integrin-alpha FG-GAP repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108648.2 → NP_001102118.2  KICSTOR complex protein ITFG2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AHW3, A6IM12, D4A716
      Related
      ENSRNOP00000061416.3, ENSRNOT00000064215.5
      Conserved Domains (2) summary
      pfam15907
      Location:49 → 382
      Itfg2; Integrin-alpha FG-GAP repeat-containing protein 2
      cl24051
      Location:22 → 54
      BBS2_Mid; Ciliary BBSome complex subunit 2, middle region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      163371125..163384676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237410.5 → XP_006237472.1  KICSTOR complex protein ITFG2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0S3, D4A716
      Related
      ENSRNOP00000084745.1, ENSRNOT00000115269.2
      Conserved Domains (2) summary
      pfam15907
      Location:49 → 364
      Itfg2; Integrin-alpha FG-GAP repeat-containing protein 2
      cl24051
      Location:21 → 54
      BBS2_Mid; Ciliary BBSome complex subunit 2, middle region

    2. XM_063286363.1 → XP_063142433.1  KICSTOR complex protein ITFG2 isoform X2

      UniProtKB/TrEMBL
      D4A716

    3. XM_063286362.1 → XP_063142432.1  KICSTOR complex protein ITFG2 isoform X1

      UniProtKB/TrEMBL
      D4A716

    4. XM_063286366.1 → XP_063142436.1  KICSTOR complex protein ITFG2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNV3, D4A716
      Related
      ENSRNOP00000092886.2, ENSRNOT00000104890.2

    5. XM_063286364.1 → XP_063142434.1  KICSTOR complex protein ITFG2 isoform X3

      UniProtKB/TrEMBL
      D4A716

    6. XM_063286367.1 → XP_063142437.1  KICSTOR complex protein ITFG2 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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