Speg striated muscle enriched protein kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spegprovided by RGD
Official Full Name: striated muscle enriched protein kinaseprovided by RGD
Primary source: RGD:2124
See related: EnsemblRapid:ENSRNOG00000019850 AllianceGenome:RGD:2124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Apeg1; APEG-1
Summary: Predicted to enable protein kinase activity. Involved in muscle cell differentiation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 111.7), Heart (RPKM 75.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84314387..84371816)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76865714..76923170)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82571333..82628684)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.
Title: Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128701 (e-PCR)
- UniSTS:212009

REN52878 (e-PCR)
- UniSTS:377678

U57098 (e-PCR)
- UniSTS:185440

D1Bwg1450e (e-PCR), detects polymorphism
- UniSTS:142231

D9Rat8 (e-PCR), detects polymorphism
- UniSTS:119198

RH139048 (e-PCR)
- UniSTS:221134

BE098213 (e-PCR)
- UniSTS:245198

REN53031 (e-PCR)
- UniSTS:377831

D9Mco71 (e-PCR)
- UniSTS:518637

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle structure development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: striated muscle-specific serine/threonine-protein kinase

Names: SPEG complex locus; aortic preferentially expressed gene 1; aortic preferentially expressed protein 1

NP_001102272.1

EC 2.7.11.1

NP_037037.1

EC 2.7.11.1

XP_006245314.1

EC 2.7.11.1

XP_006245317.1

EC 2.7.11.1

XP_006245318.1

EC 2.7.11.1

XP_017452015.1

EC 2.7.11.1

XP_017452016.1

EC 2.7.11.1

XP_017452017.1

EC 2.7.11.1

XP_017452018.1

EC 2.7.11.1

XP_038939815.1

EC 2.7.11.1

XP_038939816.1

EC 2.7.11.1

XP_038939818.1

EC 2.7.11.1

XP_038939820.1

EC 2.7.11.1

XP_038939821.1

EC 2.7.11.1

XP_063123482.1

EC 2.7.11.1

XP_063123483.1

EC 2.7.11.1

XP_063123484.1

EC 2.7.11.1

XP_063123485.1

EC 2.7.11.1

XP_063123486.1

EC 2.7.11.1

XP_063123487.1

EC 2.7.11.1

XP_063123488.1

EC 2.7.11.1

XP_063123489.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108802.2 → NP_001102272.1 striated muscle-specific serine/threonine-protein kinase isoform 1

See identical proteins and their annotated locations for NP_001102272.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q63638

UniProtKB/TrEMBL

A0A8I6ADG2, A6JW28

Related

ENSRNOP00000026941.4, ENSRNOT00000026941.9

Conserved Domains (9) summary

cd00096
Location:62 → 124

Ig; Immunoglobulin domain

smart00408
Location:1082 → 1148

IGc2; Immunoglobulin C-2 Type

smart00220
Location:1606 → 1859

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam07679
Location:727 → 816

I-set; Immunoglobulin I-set domain

cd14108
Location:1603 → 1859

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:817 → 873

SPEG_u2; Unstructured region on SPEG complex protein

pfam17061
Location:2787 → 2947

PARM; PARM

cl11960
Location:750 → 809

Ig; Immunoglobulin domain

cl21453
Location:2954 → 3210

PKc_like; Protein Kinases, catalytic domain
NM_012905.2 → NP_037037.1 striated muscle-specific serine/threonine-protein kinase isoform 4

See identical proteins and their annotated locations for NP_037037.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1. This variant corresponds to the mouse APEG-1 variant described in PubMed ID: 10973969.

Source sequence(s)

BC087690, EV763588

UniProtKB/TrEMBL

A0A8L2QUK8, A6JW29

Conserved Domains (2) summary

smart00408
Location:33 → 100

IGc2; Immunoglobulin C-2 Type

pfam07679
Location:20 → 110

I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

84314387..84371816

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267416.1 → XP_063123486.1 striated muscle-specific serine/threonine-protein kinase isoform X12

UniProtKB/TrEMBL

A0A8I5ZN28
XM_039083887.2 → XP_038939815.1 striated muscle-specific serine/threonine-protein kinase isoform X1

UniProtKB/TrEMBL

A0A8I6ADG2

Conserved Domains (8) summary

PHA03247
Location:324 → 681

PHA03247; large tegument protein UL36; Provisional

cd14108
Location:1613 → 1869

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:827 → 883

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:737 → 826

I-set; Immunoglobulin I-set domain

cd00096
Location:1079 → 1082

Ig; Ig strand A [structural motif]

cd20975
Location:884 → 974

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:1079 → 1168

Ig; Immunoglobulin domain

cl21453
Location:2964 → 3220

PKc_like; Protein Kinases, catalytic domain
XM_063267412.1 → XP_063123482.1 striated muscle-specific serine/threonine-protein kinase isoform X2

UniProtKB/TrEMBL

A0A8I6ADG2
XM_039083888.2 → XP_038939816.1 striated muscle-specific serine/threonine-protein kinase isoform X3

UniProtKB/TrEMBL

A0A8I6ADG2

Conserved Domains (8) summary

PHA03247
Location:265 → 622

PHA03247; large tegument protein UL36; Provisional

cd14108
Location:1554 → 1810

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:768 → 824

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:678 → 767

I-set; Immunoglobulin I-set domain

cd00096
Location:1020 → 1023

Ig; Ig strand A [structural motif]

cd20975
Location:825 → 915

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:1020 → 1109

Ig; Immunoglobulin domain

cl21453
Location:2905 → 3161

PKc_like; Protein Kinases, catalytic domain
XM_039083892.2 → XP_038939820.1 striated muscle-specific serine/threonine-protein kinase isoform X8

Conserved Domains (5) summary

PHA03247
Location:324 → 681

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:827 → 883

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:737 → 826

I-set; Immunoglobulin I-set domain

cd00096
Location:736 → 739

Ig; Ig strand A [structural motif]

cd20975
Location:884 → 974

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_039083893.2 → XP_038939821.1 striated muscle-specific serine/threonine-protein kinase isoform X9

UniProtKB/TrEMBL

A0A8I5ZN28

Conserved Domains (5) summary

PHA03247
Location:324 → 681

PHA03247; large tegument protein UL36; Provisional

pfam16650
Location:827 → 883

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:737 → 826

I-set; Immunoglobulin I-set domain

cd00096
Location:736 → 739

Ig; Ig strand A [structural motif]

cd20975
Location:884 → 974

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains
XM_063267415.1 → XP_063123485.1 striated muscle-specific serine/threonine-protein kinase isoform X11

UniProtKB/TrEMBL

A0A8I5ZN28
XM_063267417.1 → XP_063123487.1 striated muscle-specific serine/threonine-protein kinase isoform X13
XM_006245252.5 → XP_006245314.1 striated muscle-specific serine/threonine-protein kinase isoform X6

Conserved Domains (8) summary

PHA03247
Location:1206 → 1607

PHA03247; large tegument protein UL36; Provisional

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2219 → 2475

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cd00096
Location:334 → 337

Ig; Ig strand A [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:334 → 423

Ig; Immunoglobulin domain
XM_063267414.1 → XP_063123484.1 striated muscle-specific serine/threonine-protein kinase isoform X10

UniProtKB/TrEMBL

A0A8I5ZN28
XM_063267418.1 → XP_063123488.1 striated muscle-specific serine/threonine-protein kinase isoform X14

UniProtKB/TrEMBL

A0A8I5ZN28

Related

ENSRNOP00000084140.2, ENSRNOT00000098450.2
XM_063267419.1 → XP_063123489.1 striated muscle-specific serine/threonine-protein kinase isoform X15

UniProtKB/TrEMBL

A0A8I5ZN28
XM_017596526.3 → XP_017452015.1 striated muscle-specific serine/threonine-protein kinase isoform X4

UniProtKB/TrEMBL

A0A8I6ADG2

Conserved Domains (9) summary

cd00096
Location:933 → 1003

Ig; Immunoglobulin domain

smart00408
Location:1025 → 1091

IGc2; Immunoglobulin C-2 Type

smart00220
Location:1549 → 1802

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam07679
Location:670 → 759

I-set; Immunoglobulin I-set domain

cd14108
Location:1546 → 1802

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:760 → 816

SPEG_u2; Unstructured region on SPEG complex protein

pfam17061
Location:2730 → 2890

PARM; PARM

cl11960
Location:693 → 752

Ig; Immunoglobulin domain

cl21453
Location:2897 → 3153

PKc_like; Protein Kinases, catalytic domain
XM_017596527.3 → XP_017452016.1 striated muscle-specific serine/threonine-protein kinase isoform X5

UniProtKB/TrEMBL

A0A8I6ADG2

Related

ENSRNOP00000105531.1, ENSRNOT00000122671.1
XM_039083890.2 → XP_038939818.1 striated muscle-specific serine/threonine-protein kinase isoform X6

Conserved Domains (8) summary

PHA03247
Location:1206 → 1607

PHA03247; large tegument protein UL36; Provisional

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2219 → 2475

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cd00096
Location:334 → 337

Ig; Ig strand A [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:334 → 423

Ig; Immunoglobulin domain
XM_017596529.2 → XP_017452018.1 striated muscle-specific serine/threonine-protein kinase isoform X6

Conserved Domains (8) summary

PHA03247
Location:1206 → 1607

PHA03247; large tegument protein UL36; Provisional

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2219 → 2475

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cd00096
Location:334 → 337

Ig; Ig strand A [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:334 → 423

Ig; Immunoglobulin domain
XM_017596528.3 → XP_017452017.1 striated muscle-specific serine/threonine-protein kinase isoform X6

Conserved Domains (8) summary

PHA03247
Location:1206 → 1607

PHA03247; large tegument protein UL36; Provisional

cd14108
Location:868 → 1124

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

cd14111
Location:2219 → 2475

STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam16650
Location:82 → 138

SPEG_u2; Unstructured region on SPEG complex protein

pfam07679
Location:755 → 844

I-set; Immunoglobulin I-set domain

cd00096
Location:334 → 337

Ig; Ig strand A [structural motif]

cd20975
Location:139 → 229

IgI_APEG-1_like; Immunoglobulin-like domain of human Aortic Preferentially Expressed Protein-1 (APEG-1) and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:334 → 423

Ig; Immunoglobulin domain
XM_063267413.1 → XP_063123483.1 striated muscle-specific serine/threonine-protein kinase isoform X6
XM_006245255.5 → XP_006245317.1 striated muscle-specific serine/threonine-protein kinase isoform X7

See identical proteins and their annotated locations for XP_006245317.1

Conserved Domains (8) summary

cd00096
Location:136 → 206

Ig; Immunoglobulin domain

smart00408
Location:228 → 294

IGc2; Immunoglobulin C-2 Type

smart00220
Location:752 → 1005

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam07679
Location:636 → 725

I-set; Immunoglobulin I-set domain

cd14108
Location:749 → 1005

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam17061
Location:1933 → 2093

PARM; PARM

cl11960
Location:356 → 428

Ig; Immunoglobulin domain

cl21453
Location:2100 → 2356

PKc_like; Protein Kinases, catalytic domain
XM_006245256.5 → XP_006245318.1 striated muscle-specific serine/threonine-protein kinase isoform X7

See identical proteins and their annotated locations for XP_006245318.1

Conserved Domains (8) summary

cd00096
Location:136 → 206

Ig; Immunoglobulin domain

smart00408
Location:228 → 294

IGc2; Immunoglobulin C-2 Type

smart00220
Location:752 → 1005

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam07679
Location:636 → 725

I-set; Immunoglobulin I-set domain

cd14108
Location:749 → 1005

STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase

pfam17061
Location:1933 → 2093

PARM; PARM

cl11960
Location:356 → 428

Ig; Immunoglobulin domain

cl21453
Location:2100 → 2356

PKc_like; Protein Kinases, catalytic domain