U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Rspo4 R-spondin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499918, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rspo4provided by RGD
    Official Full Name
    R-spondin 4provided by RGD
    Primary source
    RGD:1563415
    See related
    EnsemblRapid:ENSRNOG00000009662 AllianceGenome:RGD:1563415
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563415
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within nail development. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 4. Orthologous to human RSPO4 (R-spondin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 4.1), Lung (RPKM 2.8) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rspo4 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160817611..160852071)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (140357256..140391780)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147358690..147391719)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486185 Neighboring gene proteasome inhibitor subunit 1 Neighboring gene heterogeneous nuclear ribonucleoprotein H1, pseudogene 2 Neighboring gene uncharacterized LOC120101753 Neighboring gene angiopoietin 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. Ishii Y, et al. J Invest Dermatol, 2008 Apr. PMID 17805348
    2. The complex world of WNT receptor signalling. Niehrs C. Nat Rev Mol Cell Biol, 2012 Dec. PMID 23151663
    3. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Szenker-Ravi E, et al. Nature, 2018 May. PMID 29769720
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within nail development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    R-spondin-4
    Names
    R-spondin family, member 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160817611..160852071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235262.5 → XP_006235324.1  R-spondin-4 isoform X1

      UniProtKB/TrEMBL
      D4ACX0
      Related
      ENSRNOP00000012951.5, ENSRNOT00000012951.8
      Conserved Domains (2) summary
      smart00261
      Location:85 → 126
      FU; Furin-like repeats
      pfam15913
      Location:35 → 138
      Furin-like_2; Furin-like repeat, cysteine-rich

    2. XM_063285081.1 → XP_063141151.1  R-spondin-4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.