Clec7a C-type lectin domain containing 7A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clec7aprovided by RGD
Official Full Name: C-type lectin domain containing 7Aprovided by RGD
Primary source: RGD:1565140
See related: EnsemblRapid:ENSRNOG00000054251 AllianceGenome:RGD:1565140
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Clec7b; RGD1565140
Summary: Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to fungus. Predicted to act upstream of or within several processes, including regulation of calcineurin-NFAT signaling cascade; regulation of gene expression; and response to fungus. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 267.3), Spleen (RPKM 55.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164588737..164599953, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (162902731..162913931, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163216152..163227367, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of CARD9 in inflammatory signal pathway of peritoneal macrophages in severe acute pancreatitis.
Title: Role of CARD9 in inflammatory signal pathway of peritoneal macrophages in severe acute pancreatitis.
Syk is critical for Dectin-1-mediated activation of mast cells, although the signaling differs from that triggered by FcRI activation
Title: Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.
Dectin-1 and IL-17, which were believed to be the major anti-fungus mechanisms, are Th2 independent and dispensable for clearance of S. schenckii infection.
Title: Taenia taeniaeformis in rat favors protracted skin lesions caused by Sporothrix schenckii infection: Dectin-1 and IL-17 are dispensable for clearance of this fungus.
Dectin1 activation of beta-(1-3)/(1-6)-D-glucan produces an anti-mastitis effect in rats
Title: Dectin1 activation of β-(1-3)/(1-6)-D-glucan produces an anti-mastitis effect in rats.
Dectin-1 binds fungal beta-glucan and activates innate immune signaling and also plays essential roles in immune responses against fungi.
Title: Characterization of rat beta-glucan receptor dectin-1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IBA Inferred from Biological aspect of Ancestor more info
enables (1->3)-beta-D-glucan binding	ISO Inferred from Sequence Orthology more info
enables (1->3)-beta-D-glucan immune receptor activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables opsonin binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell activation	ISO Inferred from Sequence Orthology more info
involved_in cell recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to molecule of fungal origin	ISO Inferred from Sequence Orthology more info
involved_in detection of molecule of fungal origin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of yeast	ISO Inferred from Sequence Orthology more info
involved_in detection of yeast	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, recognition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to molecule of fungal origin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to yeast	ISO Inferred from Sequence Orthology more info
involved_in response to yeast	ISO Inferred from Sequence Orthology more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 7 member A

Names: C-type lectin domain family 7, member A; dectin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173386.1 → NP_001166857.1 C-type lectin domain family 7 member A

See identical proteins and their annotated locations for NP_001166857.1

Status: PROVISIONAL

Source sequence(s)

BC166774

UniProtKB/TrEMBL

A0A0G2JW33, B5BUZ1, E9PTB9

Related

ENSRNOP00000073639.1, ENSRNOT00000091552.3

Conserved Domains (2) summary

cd03593
Location:110 → 233

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:34 → 61

Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

164588737..164599953 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237100.5 → XP_006237162.1 C-type lectin domain family 7 member A isoform X2

See identical proteins and their annotated locations for XP_006237162.1

UniProtKB/TrEMBL

B5BUZ2, E9PTT6

Related

ENSRNOP00000087024.1, ENSRNOT00000108367.2

Conserved Domains (3) summary

cd03593
Location:65 → 188

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

PHA03097
Location:24 → 186

PHA03097; C-type lectin-like protein; Provisional

pfam08391
Location:34 → 56

Ly49; Ly49-like protein, N-terminal region
XM_039108259.2 → XP_038964187.1 C-type lectin domain family 7 member A isoform X1

UniProtKB/TrEMBL

A6IM50

Related

ENSRNOP00000069723.3, ENSRNOT00000077793.3

Conserved Domains (2) summary

cd03593
Location:110 → 193

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:34 → 61

Ly49; Ly49-like protein, N-terminal region
XM_039108260.1 → XP_038964188.1 C-type lectin domain family 7 member A isoform X3

Conserved Domains (1) summary

pfam08391
Location:34 → 61

Ly49; Ly49-like protein, N-terminal region